Elemental maps in human allantochorial placental vessels cells. 4. Isoproterenol and sodium nitroprusside effects
Langue
en
Article de revue
Ce document a été publié dans
Cellular and Molecular Biology. 2004, vol. 50, p. 609-615
CMB Association
Résumé en anglais
The ionic channels (particularly, K+ and Ca2+ channels) regulate, via the membrane potential, the ionic distribution into the vascular cells. Micro-particule induced X-ray emission (PIXE) analysis was applied to determine ...Lire la suite >
The ionic channels (particularly, K+ and Ca2+ channels) regulate, via the membrane potential, the ionic distribution into the vascular cells. Micro-particule induced X-ray emission (PIXE) analysis was applied to determine the ionic composition of vascular smooth muscle cells (VSMCs) and of vascular endothelial cells (VECs) in the placental human allantochorial vessels in a physiological medium (Hanks' solution) modified by the addition of a NO donor (sodium nitroprusside, SNP) and of a beta-adrenergic stimulator (isoproterenol, ISO). The addition of SNP or ISO induced no modification of the Na, K, Cl, P, S, Mg and Ca concentrations in VSMCs. In VECs, a same effect was observed except an increase of the Mg concentration with ISO. Theses results indicated a retroactive control (active feedback) of the internal ionic distribution by endothelial factors, ionic channels and exchangers.< Réduire
Mots clés en anglais
ionic channels
isoproterenol
microanalysis
micro-PIXE
placental vessels
scanning proton microprobe
sodium nitroprusside
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