Elemental maps in human allantochorial placental vessels cells. 4. Isoproterenol and sodium nitroprusside effects
Language
en
Article de revue
This item was published in
Cellular and Molecular Biology. 2004, vol. 50, p. 609-615
CMB Association
English Abstract
The ionic channels (particularly, K+ and Ca2+ channels) regulate, via the membrane potential, the ionic distribution into the vascular cells. Micro-particule induced X-ray emission (PIXE) analysis was applied to determine ...Read more >
The ionic channels (particularly, K+ and Ca2+ channels) regulate, via the membrane potential, the ionic distribution into the vascular cells. Micro-particule induced X-ray emission (PIXE) analysis was applied to determine the ionic composition of vascular smooth muscle cells (VSMCs) and of vascular endothelial cells (VECs) in the placental human allantochorial vessels in a physiological medium (Hanks' solution) modified by the addition of a NO donor (sodium nitroprusside, SNP) and of a beta-adrenergic stimulator (isoproterenol, ISO). The addition of SNP or ISO induced no modification of the Na, K, Cl, P, S, Mg and Ca concentrations in VSMCs. In VECs, a same effect was observed except an increase of the Mg concentration with ISO. Theses results indicated a retroactive control (active feedback) of the internal ionic distribution by endothelial factors, ionic channels and exchangers.Read less <
English Keywords
ionic channels
isoproterenol
microanalysis
micro-PIXE
placental vessels
scanning proton microprobe
sodium nitroprusside
Origin
Hal imported