PHAM, T.Q.; ANNE, A.; BONY, M.; DELAGE, E.; DONNARIEIX, D.; DUFAURE, A.; GAUTIER, M.; LEE, S.B.; MICHEAU, P.; MONTAROU, G.; PERROT, Y.; SHIN, J.I.; INCERTI, S.; MAIGNE, L.

doi:10.1016/j.nimb.2015.04.024

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PHAM, T.Q.
Laboratoire de Physique Corpusculaire - Clermont-Ferrand [LPC]

ANNE, A.
Laboratoire de Physique Corpusculaire - Clermont-Ferrand [LPC]

BONY, M.
Laboratoire de Physique Corpusculaire - Clermont-Ferrand [LPC]

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Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 2015, vol. 353, p. 46–55

Elsevier

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The GATE Monte Carlo simulation platform based on the Geant4 toolkit is in constant improvement for dosimetric calculations. In this paper, we present the integration of Geant4-DNA processes into the GATE 7.0 platform in the objective to perform multi-scale simulations (from macroscopic to nanometer scale). We simulated three types of clinical and preclinical beams: a 6 MeV electron clinical beam, a X-ray irradiator beam and a clinical proton beam for which we validated depth dose distributions against measurements in water. Frequencies of energy depositions and DNA damage were evaluated using a specific algorithm in charge of allocating energy depositions to atoms constituting DNA molecules represented by their PDB (Protein Data Bank) description.< Réduire

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Nanodosimetry

Monte Carlo

GATE

Geant4-DNA

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Coupling of Geant4-DNA physics models into the GATE Monte Carlo platform: Evaluation of radiation-induced damage for clinical and preclinical radiation therapy beams

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