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Coupling of Geant4-DNA physics models into the GATE Monte Carlo platform: Evaluation of radiation-induced damage for clinical and preclinical radiation therapy beams

hal.structure.identifierLaboratoire de Physique Corpusculaire - Clermont-Ferrand [LPC]
dc.contributor.authorPHAM, T.Q.
hal.structure.identifierLaboratoire de Physique Corpusculaire - Clermont-Ferrand [LPC]
dc.contributor.authorANNE, A.
hal.structure.identifierLaboratoire de Physique Corpusculaire - Clermont-Ferrand [LPC]
dc.contributor.authorBONY, M.
hal.structure.identifierLaboratoire de Physique Corpusculaire - Clermont-Ferrand [LPC]
dc.contributor.authorDELAGE, E.
hal.structure.identifierLaboratoire de Physique Corpusculaire - Clermont-Ferrand [LPC]
hal.structure.identifierCentre Jean Perrin [Clermont-Ferrand] [UNICANCER/CJP]
dc.contributor.authorDONNARIEIX, D.
hal.structure.identifierLaboratoire de Physique Corpusculaire - Clermont-Ferrand [LPC]
dc.contributor.authorDUFAURE, A.
hal.structure.identifierLaboratoire de Physique Corpusculaire - Clermont-Ferrand [LPC]
dc.contributor.authorGAUTIER, M.
hal.structure.identifierProton Therapy Center
dc.contributor.authorLEE, S.B.
hal.structure.identifierLaboratoire de Physique Corpusculaire - Clermont-Ferrand [LPC]
dc.contributor.authorMICHEAU, P.
hal.structure.identifierLaboratoire de Physique Corpusculaire - Clermont-Ferrand [LPC]
dc.contributor.authorMONTAROU, G.
hal.structure.identifierLaboratoire de Physique Corpusculaire - Clermont-Ferrand [LPC]
dc.contributor.authorPERROT, Y.
hal.structure.identifierProton Therapy Center
dc.contributor.authorSHIN, J.I.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorINCERTI, S.
hal.structure.identifierLaboratoire de Physique Corpusculaire - Clermont-Ferrand [LPC]
dc.contributor.authorMAIGNE, L.
dc.date.issued2015
dc.identifier.issn0168-583X
dc.description.abstractEnThe GATE Monte Carlo simulation platform based on the Geant4 toolkit is in constant improvement for dosimetric calculations. In this paper, we present the integration of Geant4-DNA processes into the GATE 7.0 platform in the objective to perform multi-scale simulations (from macroscopic to nanometer scale). We simulated three types of clinical and preclinical beams: a 6 MeV electron clinical beam, a X-ray irradiator beam and a clinical proton beam for which we validated depth dose distributions against measurements in water. Frequencies of energy depositions and DNA damage were evaluated using a specific algorithm in charge of allocating energy depositions to atoms constituting DNA molecules represented by their PDB (Protein Data Bank) description.
dc.language.isoen
dc.publisherElsevier
dc.subject.enNanodosimetry
dc.subject.enMonte Carlo
dc.subject.enGATE
dc.subject.enGeant4-DNA
dc.title.enCoupling of Geant4-DNA physics models into the GATE Monte Carlo platform: Evaluation of radiation-induced damage for clinical and preclinical radiation therapy beams
dc.typeArticle de revue
dc.identifier.doi10.1016/j.nimb.2015.04.024
dc.subject.halInformatique [cs]/Modélisation et simulation
bordeaux.journalNuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
bordeaux.page46–55
bordeaux.volume353
bordeaux.peerReviewedoui
hal.identifierhal-01288784
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01288784v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nuclear%20Instruments%20and%20Methods%20in%20Physics%20Research%20Section%20B:%20Beam%20Interactions%20with%20Materials%20and%20Atoms&rft.date=2015&rft.volume=353&rft.spage=46%E2%80%9355&rft.epage=46%E2%80%9355&rft.eissn=0168-583X&rft.issn=0168-583X&rft.au=PHAM,%20T.Q.&ANNE,%20A.&BONY,%20M.&DELAGE,%20E.&DONNARIEIX,%20D.&rft.genre=article


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