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Single $\alpha$-particle irradiation permits real-time visualization of RNF8 accumulation at DNA damaged sites

hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorMUGGIOLU, Giovanna
hal.structure.identifierLaboratoire d'Intégration des Systèmes et des Technologies [LIST (CEA)]
dc.contributor.authorPOMORSKI, Michal
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorCLAVERIE, Gérard
hal.structure.identifierLaboratoire d'Intégration des Systèmes et des Technologies [LIST (CEA)]
dc.contributor.authorBERTHET, Guillaume
hal.structure.identifierLaboratoire d'Intégration des Systèmes et des Technologies [LIST (CEA)]
dc.contributor.authorMER-CALFATI, Christine
hal.structure.identifierLaboratoire d'Intégration des Systèmes et des Technologies [LIST (CEA)]
dc.contributor.authorSAADA, Samuel
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorDEVÈS, Guillaume
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorSIMON, Marina
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorSEZNEC, Herve
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorBARBERET, Philippe
IDREF: 078137748
dc.date.accessioned2022-04-19T12:59:32Z
dc.date.available2022-04-19T12:59:32Z
dc.date.issued2017
dc.identifier.issn2045-2322
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/137274
dc.description.abstractEnAs well as being a significant source of environmental radiation exposure, α-particles are increasinglyconsidered for use in targeted radiation therapy. A better understanding of α-particle induced damageat the DNA scale can be achieved by following their tracks in real-time in targeted living cells. Focusedα-particle microbeams can facilitate this but, due to their low energy (up to a few MeV) and limitedrange, α-particles detection, delivery, and follow-up observations of radiation-induced damage remaindifficult. In this study, we developed a thin Boron-doped Nano-Crystalline Diamond membrane thatallows reliable single α-particles detection and single cell irradiation with negligible beam scattering.The radiation-induced responses of single 3MeV α-particles delivered with focused microbeam arevisualized in situ over thirty minutes after irradiation by the accumulation of the GFP-tagged RNF8protein at DNA damaged sites.
dc.language.isoen
dc.publisherNature Publishing Group
dc.title.enSingle $\alpha$-particle irradiation permits real-time visualization of RNF8 accumulation at DNA damaged sites
dc.typeArticle de revue
dc.identifier.doi10.1038/srep41764
dc.subject.halPhysique [physics]
bordeaux.journalScientific Reports
bordeaux.page41764
bordeaux.volume7
bordeaux.hal.laboratoriesCentre d'Études Nucléaires de Bordeaux Gradignan (CENBG)*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01763042
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01763042v1
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