BARBERET, Philippe; POMORSKI, Michal; MUGGIOLU, Giovanna; TORFEH, Eva; CLAVERIE, Gérard; HUSS, Cédric; SAADA, Samuel; DEVÈS, Guillaume; SIMON, Marina; SEZNEC, Hervé

doi:10.1063/1.5009713

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BARBERET, Philippe
Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]

POMORSKI, Michal
Laboratoire Capteurs Diamant (CEA, LIST) [LCD (CEA, LIST)]

MUGGIOLU, Giovanna
Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]

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Ce document a été publié dans

Applied Physics Letters. 2017-12-11, vol. 111, n° 24, p. 243701

American Institute of Physics

Résumé en anglais

We report the development of thin single crystal diamond membranes suitable for dose control in targeted cell irradiation experiments with a proton microbeam. A specific design was achieved to deliver single protons with a hit detection efficiency approaching 100%. The membranes have thicknesses between 1.8 and 3 pm and arc used as vacuum windows on the microbeam line. The impact of these transmission detectors on the microbeam spot size is estimated by Monte-Carlo simulations, indicating that a beam lateral resolution below 2 µm is achieved. This is confirmed by experiments showing the accumulation online of X-ray Repair Cross-Complementing protein 1 (XRCC1)-Green Fluorescent Protein (GFP) at DNA damaged sites in living cells.< Réduire

Mots clés en anglais

CHARGED-PARTICLE MICROBEAM

SINGLE

REPAIR

RECRUITMENT

DOI

http://dx.doi.org/10.1063/1.5009713

Projet Européen

Support of Public and Industrial Research using Ion Beam Technology
Supporting Postgraduate Research with Internships in industry and Training Excellence

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Centre d'Études Nucléaires de Bordeaux Gradignan (CENBG)