Cell micro-irradiation with MeV protons counted by an ultra-thin diamond membrane
hal.structure.identifier | Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG] | |
dc.contributor.author | BARBERET, Philippe | |
hal.structure.identifier | Laboratoire Capteurs Diamant (CEA, LIST) [LCD (CEA, LIST)] | |
dc.contributor.author | POMORSKI, Michal | |
hal.structure.identifier | Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG] | |
dc.contributor.author | MUGGIOLU, Giovanna | |
hal.structure.identifier | Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG] | |
dc.contributor.author | TORFEH, Eva | |
hal.structure.identifier | Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG] | |
dc.contributor.author | CLAVERIE, Gérard | |
hal.structure.identifier | Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG] | |
dc.contributor.author | HUSS, Cédric | |
hal.structure.identifier | Laboratoire Capteurs Diamant (CEA, LIST) [LCD (CEA, LIST)] | |
dc.contributor.author | SAADA, Samuel | |
hal.structure.identifier | Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG] | |
dc.contributor.author | DEVÈS, Guillaume | |
hal.structure.identifier | Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG] | |
dc.contributor.author | SIMON, Marina | |
hal.structure.identifier | Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG] | |
dc.contributor.author | SEZNEC, Hervé | |
dc.date.issued | 2017-12-11 | |
dc.identifier.issn | 0003-6951 | |
dc.description.abstractEn | We report the development of thin single crystal diamond membranes suitable for dose control in targeted cell irradiation experiments with a proton microbeam. A specific design was achieved to deliver single protons with a hit detection efficiency approaching 100%. The membranes have thicknesses between 1.8 and 3 pm and arc used as vacuum windows on the microbeam line. The impact of these transmission detectors on the microbeam spot size is estimated by Monte-Carlo simulations, indicating that a beam lateral resolution below 2 µm is achieved. This is confirmed by experiments showing the accumulation online of X-ray Repair Cross-Complementing protein 1 (XRCC1)-Green Fluorescent Protein (GFP) at DNA damaged sites in living cells. | |
dc.language.iso | en | |
dc.publisher | American Institute of Physics | |
dc.subject.en | CHARGED-PARTICLE MICROBEAM | |
dc.subject.en | SINGLE | |
dc.subject.en | REPAIR | |
dc.subject.en | RECRUITMENT | |
dc.title.en | Cell micro-irradiation with MeV protons counted by an ultra-thin diamond membrane | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1063/1.5009713 | |
dc.subject.hal | Sciences de l'ingénieur [physics]/Micro et nanotechnologies/Microélectronique | |
dc.subject.hal | Physique [physics]/Physique [physics]/Instrumentations et Détecteurs [physics.ins-det] | |
dc.subject.hal | Physique [physics]/Physique Nucléaire Expérimentale [nucl-ex] | |
dc.subject.hal | Informatique [cs]/Modélisation et simulation | |
dc.description.sponsorshipEurope | Support of Public and Industrial Research using Ion Beam Technology | |
dc.description.sponsorshipEurope | Supporting Postgraduate Research with Internships in industry and Training Excellence | |
bordeaux.journal | Applied Physics Letters | |
bordeaux.page | 243701 | |
bordeaux.volume | 111 | |
bordeaux.issue | 24 | |
bordeaux.peerReviewed | oui | |
hal.identifier | cea-01874782 | |
hal.version | 1 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//cea-01874782v1 | |
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