Complex cell geometry and sources distribution model for Monte Carlo single cell dosimetry with iodine 125 radioimmunotherapy
BORDAGE, Marie-Claude
LAboratoire PLasma et Conversion d'Energie [LAPLACE]
Centre de Recherches en Cancérologie de Toulouse [CRCT]
< Leer menos
LAboratoire PLasma et Conversion d'Energie [LAPLACE]
Centre de Recherches en Cancérologie de Toulouse [CRCT]
Idioma
en
Article de revue
Este ítem está publicado en
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 2016-01, vol. 366, p. 227-233
Elsevier
Resumen en inglés
In cellular dosimetry, common assumptions consider concentric spheres for nucleus and cell and uniform radionuclides distribution. These approximations do not reflect reality, specially in the situation of radioimmunotherapy ...Leer más >
In cellular dosimetry, common assumptions consider concentric spheres for nucleus and cell and uniform radionuclides distribution. These approximations do not reflect reality, specially in the situation of radioimmunotherapy with Auger emitters, where very short-ranged electrons induce hyper localised energy deposition. A realistic cellular dosimetric model was generated to give account of the real geometry and activity distribution, for non-internalizing and internalizing antibodies (mAbs) labelled with Auger emitter I-125. The impact of geometry was studied by comparing the real geometry obtained from confocal microscopy for both cell and nucleus with volume equivalent concentric spheres. Non-uniform and uniform source distributions were considered for each mAbs distribution. Comparisons in terms of mean deposited energy per decay, energy deposition spectra and energy-volume histograms were calculated using Geant4. We conclude that realistic models are needed, especially when energy deposition is highly non-homogeneous due to source distribution.< Leer menos
Palabras clave en inglés
Monte Carlo
Cellular dosimetry
I-125
Radioimmunotherapy
Orígen
Importado de HalCentros de investigación