ARNAUD, François-Xavier; PAILLAS, S.; POUGET, Jean-Pierre; INCERTI, S.; BARDIÈS, M.; BORDAGE, Marie-Claude

doi:10.1016/j.nimb.2015.11.008

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ARNAUD, François-Xavier
LAboratoire PLasma et Conversion d'Energie [LAPLACE]

PAILLAS, S.
Institut de Recherche en Cancérologie de Montpellier [IRCM - U1194 Inserm - UM]

POUGET, Jean-Pierre
Institut de Recherche en Cancérologie de Montpellier [IRCM - U1194 Inserm - UM]

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Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 2016-01, vol. 366, p. 227-233

Elsevier

Résumé en anglais

In cellular dosimetry, common assumptions consider concentric spheres for nucleus and cell and uniform radionuclides distribution. These approximations do not reflect reality, specially in the situation of radioimmunotherapy with Auger emitters, where very short-ranged electrons induce hyper localised energy deposition. A realistic cellular dosimetric model was generated to give account of the real geometry and activity distribution, for non-internalizing and internalizing antibodies (mAbs) labelled with Auger emitter I-125. The impact of geometry was studied by comparing the real geometry obtained from confocal microscopy for both cell and nucleus with volume equivalent concentric spheres. Non-uniform and uniform source distributions were considered for each mAbs distribution. Comparisons in terms of mean deposited energy per decay, energy deposition spectra and energy-volume histograms were calculated using Geant4. We conclude that realistic models are needed, especially when energy deposition is highly non-homogeneous due to source distribution.< Réduire

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Monte Carlo

Cellular dosimetry

I-125

Radioimmunotherapy

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Complex cell geometry and sources distribution model for Monte Carlo single cell dosimetry with iodine 125 radioimmunotherapy

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