DROUET, Christophe; CHOIMET, Maëla; SIMON, Marina; DEVÈS, Guillaume; BARBERET, Philippe; SEZNEC, Hervé; RASSU, Giovanna; MARSAN, Olivier; TOURRETTE, Audrey

doi:10.19080/JOJMS.2020.06.555676

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DROUET, Christophe
Centre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT]

CHOIMET, Maëla
Centre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT]
Air liquide France Industrie

SIMON, Marina
Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]

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Ce document a été publié dans

Junipr Online Journal Material Science. 2020, vol. 6, n° 1, p. 555676

Juniper Publishers

Résumé en anglais

Calcium phosphate apatites are naturally present in all vertebrates, as a biomineral in teeth and bones. The possibility to prepare synthetic analogs in close-to-physiological conditions allows the development of bio-inspired materials for medical use. While apatite-based biomaterials are extensively developed for bone regeneration, their intrinsic biocompatibility also allows designing original applications as in nanomedicine. In this paper, we will illustrate why colloidal apatite particles can be seen as a multifunctional platform for (nano)medical uses, well beyond bone repair. Retrospective data will be summarized in this mini-review, especially relating to oncology and hematology applications of apatite colloidal particles. Then novel data will be presented, in the field of dermatology and of particle tracking, using Raman confocal microscopy and μPIXE elemental mapping on substituted apatites. By exploiting their exceptional surface and bulk reactivities, colloidal apatite particles appear as robust new comers to nanomedicine, with the capacity to exhibit tailorable functionalities.< Réduire

Mots clés en anglais

Apatite

Biomimetism

Nanoparticles

Nanomedicine

Colloid

Oncology

Hematology

Dermatology

Platform

Multifunctional

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Colloidal Apatite Particles : A Multifunctional Platform in (Nano)Medicine

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Résumé en anglais

Mots clés en anglais

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Unités de recherche