Colloidal Apatite Particles : A Multifunctional Platform in (Nano)Medicine
CHOIMET, Maëla
Centre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT]
Air liquide France Industrie
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Centre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT]
Air liquide France Industrie
CHOIMET, Maëla
Centre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT]
Air liquide France Industrie
< Reduce
Centre interuniversitaire de recherche et d'ingénierie des matériaux [CIRIMAT]
Air liquide France Industrie
Language
en
Article de revue
This item was published in
Junipr Online Journal Material Science. 2020, vol. 6, n° 1, p. 555676
Juniper Publishers
English Abstract
Calcium phosphate apatites are naturally present in all vertebrates, as a biomineral in teeth and bones. The possibility to prepare synthetic analogs in close-to-physiological conditions allows the development of bio-inspired ...Read more >
Calcium phosphate apatites are naturally present in all vertebrates, as a biomineral in teeth and bones. The possibility to prepare synthetic analogs in close-to-physiological conditions allows the development of bio-inspired materials for medical use. While apatite-based biomaterials are extensively developed for bone regeneration, their intrinsic biocompatibility also allows designing original applications as in nanomedicine. In this paper, we will illustrate why colloidal apatite particles can be seen as a multifunctional platform for (nano)medical uses, well beyond bone repair. Retrospective data will be summarized in this mini-review, especially relating to oncology and hematology applications of apatite colloidal particles. Then novel data will be presented, in the field of dermatology and of particle tracking, using Raman confocal microscopy and μPIXE elemental mapping on substituted apatites. By exploiting their exceptional surface and bulk reactivities, colloidal apatite particles appear as robust new comers to nanomedicine, with the capacity to exhibit tailorable functionalities.Read less <
English Keywords
Apatite
Biomimetism
Nanoparticles
Nanomedicine
Colloid
Oncology
Hematology
Dermatology
Platform
Multifunctional
Origin
Hal imported