SAKATA, Dousatsu; LAMPE, Nathanael; KARAMITROS, Mathieu; KYRIAKOU, Ioanna; BELOV, Oleg; BERNAL, Mario A.; BOLST, David; BORDAGE, Marie-Claude; BRETON, Vincent; BROWN, Jeremy M.C.; FRANCIS, Ziad; IVANCHENKO, Vladimir; MEYLAN, Sylvain; MURAKAMI, Koichi; OKADA, Shogo; PETROVIC, Ivan; RISTIC-FIRA, Aleksandra; SANTIN, Giovanni; SARRAMIA, David; SASAKI, Takashi; SHIN, Wook-Geun; TANG, Nicolas; TRAN, Hoang N.; VILLAGRASA, Carmen; EMFIETZOGLOU, Dimitris; NIEMINEN, Petteri; GUATELLI, Susanna; INCERTI, Sebastien

doi:10.1016/j.ejmp.2019.04.010

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SAKATA, Dousatsu

LAMPE, Nathanael
Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]

KARAMITROS, Mathieu
Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]

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Phys.Medica. 2019, vol. 62, p. 152-157

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The advancement of multidisciplinary research fields dealing with ionising radiation induced biological damage - radiobiology, radiation physics, radiation protection and, in particular, medical physics - requires a clear mechanistic understanding of how cellular damage is induced by ionising radiation. Monte Carlo (MC) simulations provide a promising approach for the mechanistic simulation of radiation transport and radiation chemistry, towards the in silico simulation of early biological damage. We have recently developed a fully integrated MC simulation that calculates early single strand breaks (SSBs) and double strand breaks (DSBs) in a fractal chromatin based human cell nucleus model. The results of this simulation are almost equivalent to past MC simulations when considering direct/indirect strand break fraction, DSB yields and fragment distribution. The simulation results agree with experimental data on DSB yields within 13.6% on average and fragment distributions agree within an average of 34.8%.< Réduire

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Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA

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