KERLOCH, Thomas; FARRUGIA, Fanny; BOUIT, Lou; MAITRE, Marlene; TERRAL, Geoffrey; KOEHL, Muriel; MORTESSAGNE, Pierre; HENG, J.I.-T.; BLANCHARD, Mylene; DOAT, Helene; LESTE-LASSERRE, Thierry; GORON, Adeline; GONZALES, Delphine; PERRAIS, David; GUILLEMOT, F.; ABROUS, Djoher Nora; PACARY, Emilie

doi:10.1038/s41380-021-01301-z

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

FARRUGIA, Fanny
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

BOUIT, Lou
Interdisciplinary Institute for Neuroscience / Institut interdisciplinaire de neurosciences [Bordeaux] [IINS]

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Ce document a été publié dans

Molecular Psychiatry. 2021-09-24, vol. 26, n° 12, p. 7280–7295

Résumé en anglais

Despite the central role of Rho GTPases in neuronal development, their functions in adult hippocampal neurogenesis remain poorly explored. Here, by using a retrovirus-based loss-of-function approach in vivo, we show that the atypical Rho GTPase Rnd2 is crucial for survival, positioning, somatodendritic morphogenesis, and functional maturation of adult-born dentate granule neurons. Interestingly, most of these functions are specific to granule neurons generated during adulthood since the deletion of Rnd2 in neonatally-born granule neurons only affects dendritogenesis. In addition, suppression of Rnd2 in adult-born dentate granule neurons increases anxiety-like behavior whereas its deletion in pups has no such effect, a finding supporting the adult neurogenesis hypothesis of anxiety disorders. Thus, our results are in line with the view that adult neurogenesis is not a simple continuation of earlier processes from development, and establish a causal relationship between Rnd2 expression and anxiety.< Réduire

URI

https://oskar-bordeaux.fr/handle/20.500.12278/136547

DOI

http://dx.doi.org/10.1038/s41380-021-01301-z

Project ANR

Développement et fonction des nouveaux neurones dans l'hippocampe adulte: exploration du rôle clé joué par Rnd2
Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043
Développment d'une infrastructure française distribuée coordonnée - ANR-10-INBS-0004

Unités de recherche

Neurocentre Magendie - U1215

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The atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis

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