LETELLIER, Noemie; GUTIERREZ, Laure‐Anne; DUCHESNE, Jeanne; CHEN, Chen; ILANGO, Sindana; HELMER, Catherine; BERR, Claudine; MORTAMAIS, Marion; BENMARHNIA, Tarik

doi:10.1002/alz.12606

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LETELLIER, Noemie

GUTIERREZ, Laure‐Anne

DUCHESNE, Jeanne

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Article de revue

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Alzheimer’s and Dementia. 2022-02-09

Résumé en anglais

INTRODUCTION: No evidence exists about the impact of air pollution reduction on incidence of dementia. The aim of this study was to quantify how air quality improvement leads to dementia-incidence benefits. METHODS: In the French Three-City cohort (12 years of follow-up), we used parametric g-computation to quantify the expected number of prevented dementia cases under different hypothetical interventions with particulate matter measuring <2.5 mum (PM2.5 ) reductions. RESULTS: Among 7051 participants, 789 participants developed dementia. The median PM2.5 reduction between 1990 and 2000 was 12.2 (mug/m(3) ). Such a reduction reduced the risk of all-cause dementia (hazard ratio [HR], 0.85; 95% confidence interval [CI], 0.76 to 0.95). If all study participants were enjoying a hypothetical reduction of more than 13.10 mug/m(3) (median reduction observed in the city of Montpellier), the rate difference was -0.37 (95% CI, -0.57 to -0.17) and the rate ratio was 0.67 (95% CI, 0.50 to 0.84). DISCUSSION: These findings highlight the possible substantial benefits of reducing air pollution in the prevention of dementia.< Réduire

Mots clés en anglais

Air pollution

Causal inference

Dementia

G-formula

Particulate matter

URI

https://oskar-bordeaux.fr/handle/20.500.12278/136446

DOI

http://dx.doi.org/10.1002/alz.12606

Project ANR

Histoire naturelle du déclin cognitif et du besoin de soins chez le sujet âgé
ABSINTE : Etude fonctionnelle de l'absorption intestinale de micronutriments liposolubles : régulation et interaction - ANR-06-PNRA-0001

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219