Diagnostic Value of (18)F-Fluorodeoxyglucose Positron Emission Tomography Computed Tomography in Prosthetic Pulmonary Valve Infective Endocarditis
VENET, Maelys
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
Institut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
Institut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
JALAL, Zakaria
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
Institut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
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Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
Institut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
VENET, Maelys
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
Institut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
Institut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
JALAL, Zakaria
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
Institut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
Institut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
THAMBO, Jean-Benoit
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
Institut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
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Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
Institut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
Langue
EN
Article de revue
Ce document a été publié dans
JACC: Cardiovascular Imaging. 2022-02, vol. 15, n° 2, p. 299-308
Résumé en anglais
OBJECTIVES: The aim of this study was to assess the diagnostic performances of (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) in congenital heart disease (CHD) patients ...Lire la suite >
OBJECTIVES: The aim of this study was to assess the diagnostic performances of (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) in congenital heart disease (CHD) patients with pulmonary prosthetic valve or conduit endocarditis (PPVE) suspicion. BACKGROUND: PPVE is a major issue in the growing CHD population. Diagnosis is challenging, and usual imaging tools are not always efficient or validated in this specific population. Particularly, the diagnostic yield of (18)F-FDG PET/CT remains poorly studied in PPVE. METHODS: A retrospective multicenter study was conducted in 8 French tertiary centers. Children and adult CHD patients who underwent (18)F-FDG PET/CT in the setting of PPVE suspicion between January 2010 and May 2020 were included. The cases were initially classified as definite, possible, or rejected PPVE regarding the modified Duke criteria and finally by the Endocarditis Team consensus. The result of (18)F-FDG PET/CT had been compared with final diagnosis consensus used as gold-standard in our study. RESULTS: A total of 66 cases of PPVE suspicion involving 59 patients (median age 23 years, 73% men) were included. Sensitivity, specificity, positive predictive value, and negative predictive value of (18)F-FDG PET/CT in PPVE suspicion were respectively: 79.1% (95% CI: 68.4%-91.4%), 72.7% (95% CI: 60.4%-85.0%), 91.9% (95% CI: 79.6%-100.0%), and 47.1% (95% CI: 34.8%-59.4%). (18)F-FDG PET/CT findings would help to correctly reclassify 57% (4 of 7) of possible PPVE to definite PPVE. CONCLUSIONS: Using (18)F-FDG PET/CT improves the diagnostic accuracy of the Duke criteria in CHD patients with suspected PPVE. Its high positive predictive value could be helpful in routine to shorten diagnosis and treatment delays and improve clinical outcomes.< Réduire
Mots clés en anglais
18F-FDG PET/CT
Congenital heart disease
Infective endocarditis
Pulmonary valve
Project ANR
L'Institut de Rythmologie et modélisation Cardiaque