MASSE, Karine; BHAMRA, S.; PAROISSIN, C.; MANETA-PEYRET, Lilly; BOUE-GRABOT, Eric; JONES, E. A.

doi:10.1038/s42003-021-02688-9

Institut des Maladies Neurodégénératives [Bordeaux] [IMN]

BHAMRA, S.

PAROISSIN, C.

Langue

Article de revue

Ce document a été publié dans

Communications biology. 2021, vol. 4, n° 1

Résumé en anglais

Abstract The enpp ectonucleotidases regulate lipidic and purinergic signalling pathways by controlling the extracellular concentrations of purines and bioactive lipids. Although both pathways are key regulators of kidney physiology and linked to human renal pathologies, their roles during nephrogenesis remain poorly understood. We previously showed that the pronephros was a major site of enpp expression and now demonstrate an unsuspected role for the conserved vertebrate enpp4 protein during kidney formation in Xenopus . Enpp4 over-expression results in ectopic renal tissues and, on rare occasion, complete mini-duplication of the entire kidney. Enpp4 is required and sufficient for pronephric markers expression and regulates the expression of RA, Notch and Wnt pathway members. Enpp4 is a membrane protein that binds, without hydrolyzing, phosphatidylserine and its effects are mediated by the receptor s1pr5, although not via the generation of S1P. Finally, we propose a novel and non-catalytic mechanism by which lipidic signalling regulates nephrogenesis.< Réduire

Mots clés en anglais

Animals

Body Patterning

Embryonic Development

Gene Regulatory Networks

Kidney

Phosphoric Diester Hydrolases

Xenopus Proteins

Xenopus laevis

URI

https://oskar-bordeaux.fr/handle/20.500.12278/136386

DOI

http://dx.doi.org/10.1038/s42003-021-02688-9

Unités de recherche

Laboratoire de Biogenèse Membranaire (LBM) - UMR 5200

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The enpp4 ectonucleotidase regulates kidney patterning signalling networks in Xenopus embryos

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche