AL HAZZOURI, Adina Zeki; JAWADEKAR, Neal; KEZIOS, Katrina; CAUNCA, Michelle R.; ELFASSY, Tali; CALONICO, Sebastian; KERSHAW, Kiarri N.; YAFFE, Kristine; LAUNER, Lenore; ELBEJJANI, Martine; GRASSET, Leslie; MANLY, Jennifer; ODDEN, Michelle C.; GLYMOUR, M. Maria

doi:10.1093/aje/kwab297

Métadonnées

Afficher la notice complète

Licence d’utilisation du document

AL HAZZOURI, Adina Zeki

JAWADEKAR, Neal

KEZIOS, Katrina

Langue

Article de revue

Ce document a été publié dans

American Journal of Epidemiology. 2022-01-11

Résumé en anglais

Racial residential segregation is associated with multiple adverse health outcomes in Black individuals. Yet, the influence of structural racism and racial residential segregation on brain aging is less understood. In this study, we investigate the association between cumulative exposure to racial residential segregation over 25 years (1985-2010) of young adulthood, measured by the Getis-Ord Gi*-statistic, and year 25 measures of brain volume in midlife (cerebral, gray matter, white matter, and hippocampal volumes). We studied 290 Black participants with available brain imaging data who were enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) prospective cohort study. CARDIA originally recruited 2637 Black participants aged 18 to 30 years old from 4 field centers across the United States. We conducted analyses using marginal structural models, incorporating inverse probability weighting and inverse censoring weighting. We found that compared to low/medium segregation, greater cumulative exposure to residential segregation throughout young adulthood was associated with smaller brain volumes in general (e.g. β for cerebral volume: -0.08 [95% CI]: [-0.15, -0.02]) and with a more pronounced reduction in hippocampal volume, though results were not statistically significant. Our findings suggest that exposure to segregated neighborhoods may be associated with worse brain aging.< Réduire

Mots clés en anglais

Brain aging

Epidemiologic methods

Marginal structural models

Racism

Segregation

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Racial Residential Segregation in Young Adulthood and Brain Integrity in Middle Age: Can We Learn From Small Samples?

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche