GAUTHIER, Audrey; VIEL, Sebastien; PERRET, Magali; BROCARD, Guillaume; CASEY, Romain; LOMBARD, Christine; LAURENT-CHABALIER, Sabine; DEBOUVERIE, Marc; EDAN, Gilles; VUKUSIC, Sandra; LEBRUN-FRENAY, Christine; DE SEZE, Jerome; LAPLAUD, David-Axel; CASTELNOVO, Giovanni; GOUT, Olivier; RUET, Aurelie; MOREAU, Thibault; CASEZ, Olivier; CLAVELOU, Pierre; BERGER, Eric; ZEPHIR, Helene; TROUILLET-ASSANT, Sophie; THOUVENOT, Eric

doi:10.1002/acn3.51355

Idioma

Article de revue

Este ítem está publicado en

Annals of Clinical and Translational Neurology. 2021-05, vol. 8, n° 5, p. 1141-1150

Resumen en inglés

We compared SimoaTM and EllaTM immunoassays to assess serum neurofilament-light chain levels in 203 multiple sclerosis patients from the OFSEP HD study. There was a strong correlation (ρ = 0.86, p < 0.0001) between both platforms. The EllaTM instrument overestimated values by 17%, but as the data were linear (p = 0.57), it was possible to apply a correction factor to EllaTM results. As for SimoaTM, serum neurofilament-light chain levels measured by EllaTM were correlated with age and EDSS and were significantly higher in active multiple sclerosis, suggesting that these assays are equivalent and can be used in routine clinical practice.< Leer menos

URI

https://oskar-bordeaux.fr/handle/20.500.12278/128748

DOI

http://dx.doi.org/10.1002/acn3.51355

Proyecto ANR

Observatoire Français de la Sclérose en Plaques

Centros de investigación

Neurocentre Magendie - U1215

Ver/Abrir

Metadatos

Compartir este ítem

Licencia de uso del documento

Comparison of Simoa™ and Ella™ to assess serum neurofilament-light chain in multiple sclerosis

Idioma

Este ítem está publicado en

Resumen en inglés

URI

DOI

Proyecto ANR

Centros de investigación