Mostrar el registro sencillo del ítem
Requirement of Phosphoinositides Containing Stearic Acid To Control Cell Polarity
| dc.rights.license | open | en_US |
| hal.structure.identifier | Laboratoire de biogenèse membranaire [LBM] | |
| dc.contributor.author | DOIGNON, Francois
ORCID: 0000-0002-9007-2408 IDREF: 097088439 | |
| hal.structure.identifier | Laboratoire de biogenèse membranaire [LBM] | |
| dc.contributor.author | LAQUEL-ROBERT, Patricia
IDREF: 31266924 | |
| hal.structure.identifier | Laboratoire de biogenèse membranaire [LBM] | |
| dc.contributor.author | TESTET, Eric
IDREF: 03328184X | |
| hal.structure.identifier | Laboratoire de biogenèse membranaire [LBM] | |
| dc.contributor.author | TUPHILE, Karine | |
| hal.structure.identifier | Laboratoire de biogenèse membranaire [LBM] | |
| dc.contributor.author | FOUILLEN, Laetitia
ORCID: 0000-0002-1204-9296 IDREF: 136936385 | |
| hal.structure.identifier | Laboratoire de biogenèse membranaire [LBM] | |
| dc.contributor.author | BESSOULE, Jean-Jacques
ORCID: 0000-0002-5717-5210 IDREF: 072151846 | |
| dc.date.accessioned | 2022-02-07T12:40:34Z | |
| dc.date.available | 2022-02-07T12:40:34Z | |
| dc.date.issued | 2016-02-16 | |
| dc.identifier.issn | 1098-5549 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/124678 | |
| dc.description.abstractEn | Phosphoinositides (PIPs) are present in very small amounts but are essential for cell signaling, morphogenesis, and polarity. By mass spectrometry, we demonstrated that some PIPs with stearic acyl chains were strongly disturbed in a psi1Δ Saccharomyces cerevisiae yeast strain deficient in the specific incorporation of a stearoyl chain at the sn-1 position of phosphatidylinositol. The absence of PIPs containing stearic acid induced disturbances in intracellular trafficking, although the total amount of PIPs was not diminished. Changes in PIPs also induced alterations in the budding pattern and defects in actin cytoskeleton organization (cables and patches). Moreover, when the PSI1 gene was impaired, a high proportion of cells with bipolar cortical actin patches that occurred concomitantly with the bipolar localization of Cdc42p was specifically found among diploid cells. This bipolar cortical actin phenotype, never previously described, was also detected in a bud9Δ/bud9Δ strain. Very interestingly, overexpression of PSI1 reversed this phenotype. | |
| dc.description.sponsorship | Développement d’une infrastructure française distribuée pour la métabolomique dédiée à l’innovation - ANR-11-INBS-0010/11-INBS-0010 | en_US |
| dc.description.sponsorship | Développment d'une infrastructure française distribuée coordonnée - ANR-10-INBS-04-01/10-INBS-0004 | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Actins | |
| dc.subject.en | Acyltransferases | |
| dc.subject.en | Cell Polarity | |
| dc.subject.en | Gene Deletion | |
| dc.subject.en | Phosphatidylinositols | |
| dc.subject.en | Saccharomyces cerevisiae | |
| dc.subject.en | Saccharomyces cerevisiae Proteins | |
| dc.subject.en | Stearic Acids | |
| dc.title.en | Requirement of Phosphoinositides Containing Stearic Acid To Control Cell Polarity | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1128/MCB.00843-15 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biologie végétale | en_US |
| dc.identifier.pubmed | 26711260 | en_US |
| bordeaux.journal | Molecular and Cellular Biology | en_US |
| bordeaux.page | 765-80 | en_US |
| bordeaux.volume | 36 | en_US |
| bordeaux.hal.laboratories | Laboratoire de Biogenèse Membranaire (LBM) - UMR 5200 | en_US |
| bordeaux.issue | 5 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-03560139 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-02-07T12:40:37Z | |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecular%20and%20Cellular%20Biology&rft.date=2016-02-16&rft.volume=36&rft.issue=5&rft.spage=765-80&rft.epage=765-80&rft.eissn=1098-5549&rft.issn=1098-5549&rft.au=DOIGNON,%20Francois&LAQUEL-ROBERT,%20Patricia&TESTET,%20Eric&TUPHILE,%20Karine&FOUILLEN,%20Laetitia&rft.genre=article |
Archivos en el ítem
| Archivos | Tamaño | Formato | Ver |
|---|---|---|---|
|
No hay archivos asociados a este ítem. |
|||