BACKGROUND: Early identification of AMD can lead to prompt and more effective treatment, better outcomes, and better final visual acuity; several risk scores have been devised to determine the individual level of risk for developing AMD. Herein, the Delphi method was used to provide recommendations for daily practice regarding preventive measures and follow-up required for subjects at low, moderate, and high risk of AMD evaluated with the Simplified Test AMD Risk-assessment Scale (STARS(®)) questionnaire. METHODS: A steering committee of three experts drafted and refined 25 statements on the approach to be recommended in different clinical situations [general recommendations (n = 2), use of evaluation tools (n = 4), general lifestyle advice (n = 3), and AREDS-based nutritional supplementation (n = 5)] with the help of a group of international experts, all co-authors of this paper. Thirty retinal specialists from Europe and the US were chosen based on relevant publications, clinical expertise, and experience in AMD, who then provided their level of agreement with the statements. Statements for which consensus was not reached were modified and voted upon again. RESULTS: In the first round of voting, consensus was reached for 24 statements. After modification, consensus was then reached for the remaining statement. CONCLUSION: An interprofessional guideline to support preventive measures in patients at risk of AMD based on STARS(®) scoring has been developed to aid clinicians in daily practice, which will help to optimize preventive care of patients at risk of AMD.< Réduire