DUBANET, Olivier; FERREIRA GOMES DA SILVA, Arnaldo; FRICK, Andreas; HIRASE, Hajime; BEYELER, Anna; LEINEKUGEL, Xavier

doi:10.1016/j.celrep.2021.109381

DUBANET, Olivier
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

FERREIRA GOMES DA SILVA, Arnaldo

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

FRICK, Andreas

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

Idioma

Article de revue

Este ítem está publicado en

Cell Reports. 2021-07-13, vol. 36, n° 2

Resumen en inglés

The hypothesis that reversed, excitatory GABA may be involved in various brain pathologies, including epileptogenesis, is appealing but controversial because of the technical difficulty of probing endogenous GABAergic synaptic function in vivo. We overcome this challenge by non-invasive extracellular recording of neuronal firing responses to optogenetically evoked and spontaneously occurring inhibitory perisomatic GABAergic field potentials, generated by individual parvalbumin interneurons on their target pyramidal cells. Our direct probing of GABAergic transmission suggests a rather anecdotal participation of excitatory GABA in two specific models of epileptogenesis in the mouse CA3 circuit in vivo, even though this does not preclude its expression in other brain areas or pathological conditions. Our approach allows the detection of distinct alterations of inhibition during spontaneous activity in vivo, with high sensitivity. It represents a promising tool for the investigation of excitatory GABA in different pathological conditions that may affect the hippocampal circuit.< Leer menos

Palabras clave en inglés

Epilepsy

GABAergic transmission

Hippocampus

Inhibition

Interneurons

URI

https://oskar-bordeaux.fr/handle/20.500.12278/124299

DOI

http://dx.doi.org/10.1016/j.celrep.2021.109381

Centros de investigación

Neurocentre Magendie - U1215

Ver/Abrir

Metadatos

Compartir este ítem

Licencia de uso del documento

Probing the polarity of spontaneous perisomatic GABAergic synaptic transmission in the mouse CA3 circuit in vivo

Idioma

Este ítem está publicado en

Resumen en inglés

Palabras clave en inglés

URI

DOI

Centros de investigación