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dc.rights.licenseopenen_US
dc.contributor.authorDANIGO, Aurore
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorROVINI, Amandine
dc.contributor.authorBESSAGUET, Flavien
dc.contributor.authorBOUCHENAKI, Hichem
dc.contributor.authorBERNARD, Amandine
dc.contributor.authorSTURTZ, Franck
dc.contributor.authorBOURTHOUMIEU, Sylvie
dc.contributor.authorDESMOULIÈRE, Alexis
dc.contributor.authorMAGY, Laurent
dc.contributor.authorDEMIOT, Claire
dc.date.accessioned2021-12-21T08:28:05Z
dc.date.available2021-12-21T08:28:05Z
dc.date.issued2021-02-24
dc.identifier.issn1424-8247en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124222
dc.description.abstractEnPreclinical evidence, accumulated over the past decade, indicates that the angiotensin II type 2 receptor (AT2R) stimulation exerts significant neuroprotective effects in various animal models of neuronal injury, notably in the central nervous system. While the atypical G protein-coupled receptor superfamily nature of AT2R and its related signaling are still under investigation, pharmacological studies have shown that stimulation of AT2R leads to neuritogenesis in vitro and in vivo. In this review, we focus on the potential neuroprotective and neuroregenerative roles of AT2R specifically in the peripheral nervous system (PNS). The first section describes the evidence for AT2R expression in the PNS and highlights current controversies concerning the cellular distribution of the receptor. The second section focuses on AT2R signaling implicated in neuronal survival and in neurite outgrowth. The following sections review the relatively few preclinical studies highlighting the putative neuroprotective and neuroregenerative effects of AT2R stimulation in the context of peripheral neuropathy.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enangiotensin II type 2 receptor
dc.subject.enneuroprotection
dc.subject.enneuroregeneration
dc.subject.enpain
dc.subject.enperipheral nervous system
dc.title.enThe Angiotensin II Type 2 Receptor, a Target for Protection and Regeneration of the Peripheral Nervous System?
dc.title.alternativePharmaceuticals (Basel)en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/ph14030175en_US
dc.subject.halSciences du Vivant [q-bio]/Biotechnologiesen_US
dc.identifier.pubmed33668331en_US
bordeaux.journalPharmaceuticalsen_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - UMR_S 1026en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-03498492
hal.version1
hal.date.transferred2021-12-21T08:28:08Z
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Pharmaceuticals&rft.date=2021-02-24&rft.volume=14&rft.issue=3&rft.eissn=1424-8247&rft.issn=1424-8247&rft.au=DANIGO,%20Aurore&ROVINI,%20Amandine&BESSAGUET,%20Flavien&BOUCHENAKI,%20Hichem&BERNARD,%20Amandine&rft.genre=article


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