DANIGO, Aurore; ROVINI, Amandine; BESSAGUET, Flavien; BOUCHENAKI, Hichem; BERNARD, Amandine; STURTZ, Franck; BOURTHOUMIEU, Sylvie; DESMOULIÈRE, Alexis; MAGY, Laurent; DEMIOT, Claire

doi:10.3390/ph14030175

ROVINI, Amandine
Bioingénierie tissulaire [BIOTIS]

BESSAGUET, Flavien

Langue

Article de revue

Ce document a été publié dans

Pharmaceuticals. 2021-02-24, vol. 14, n° 3

Résumé en anglais

Preclinical evidence, accumulated over the past decade, indicates that the angiotensin II type 2 receptor (AT2R) stimulation exerts significant neuroprotective effects in various animal models of neuronal injury, notably in the central nervous system. While the atypical G protein-coupled receptor superfamily nature of AT2R and its related signaling are still under investigation, pharmacological studies have shown that stimulation of AT2R leads to neuritogenesis in vitro and in vivo. In this review, we focus on the potential neuroprotective and neuroregenerative roles of AT2R specifically in the peripheral nervous system (PNS). The first section describes the evidence for AT2R expression in the PNS and highlights current controversies concerning the cellular distribution of the receptor. The second section focuses on AT2R signaling implicated in neuronal survival and in neurite outgrowth. The following sections review the relatively few preclinical studies highlighting the putative neuroprotective and neuroregenerative effects of AT2R stimulation in the context of peripheral neuropathy.< Réduire

Mots clés en anglais

angiotensin II type 2 receptor

neuroprotection

neuroregeneration

pain

peripheral nervous system

URI

https://oskar-bordeaux.fr/handle/20.500.12278/124222

DOI

http://dx.doi.org/10.3390/ph14030175

Unités de recherche

Bioingénierie Tissulaire (BioTis) - U1026

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The Angiotensin II Type 2 Receptor, a Target for Protection and Regeneration of the Peripheral Nervous System?

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Résumé en anglais

Mots clés en anglais

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