JASPARD, Marie; JUCHET, Sylvain; SERRA, Beatrice; MAYOUM, Baweye; KANTA, Issa Malam; CAMARA, Mohamed Seto; MBALA, Placide; KOJAN, Richard; MALVY, Denis

doi:10.1016/j.ijid.2021.09.053

JUCHET, Sylvain
Bordeaux population health [BPH]

SERRA, Beatrice
Bordeaux population health [BPH]

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Article de revue

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International Journal of Infectious Diseases. 2021-09-26, vol. 113, p. 166-167

Resumen en inglés

INTRODUCTION: With the development of therapeutics and vaccine against Ebola Virus Disease, the question of post exposure prophylaxis for high risk contact emerged. Immunotherapies (monoclonal antibodies, mAbs) recently validated for treatment of infected patients appears to be good candidate to protect contacts. DESIGN: During the 10(th) EVD outbreak in the Democratic Republic of the Congo, we have administrated mAbs (Mab114 or REGN-EB3) to high and intermediate risk contact of Ebola Virus Disease patients. RESULTS: Overall, 23 non vaccinated contacts received mAbs after a median delay between contact and post exposure prophylaxis of 1 day (IQR 1,2). 14 days after the contact, all contacts were free of symptoms and all had negative RT-PCR CONCLUSION: Immunotherapies appears to be promising candidates to protect contacts of Ebola Virus Disease. Interaction with vaccine and larger study on efficacy need to be conducted.< Leer menos

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Ebola virus disease

Post-exposure prophylaxis

Monoclonal antibodies

URI

https://oskar-bordeaux.fr/handle/20.500.12278/123989

DOI

http://dx.doi.org/10.1016/j.ijid.2021.09.053

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Bordeaux Population Health Research Center (BPH) - UMR 1219

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Post-exposure prophylaxis following high-risk contact with Ebola virus, using immunotherapies with monoclonal antibodies, in the eastern Democratic Republic of the Congo: an emergency use program

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