KAMINSKI, Hannah; MARSERES, Gabriel; COSENTINO, Anaïs; GUERVILLE, Florent; PITARD, Vincent; FOURNIÉ, Jean-Jacques; MERVILLE, Pierre; DECHANET-MERVILLE, Julie; COUZI, Lionel

doi:10.1111/imr.12922

Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

MARSERES, Gabriel

Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

COSENTINO, Anaïs
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

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Article de revue

Ce document a été publié dans

Immunological Reviews. 2020-01-01, vol. 298, n° 1, p. 264-288

Résumé en anglais

Cytomegalovirus (CMV) infection is responsible for significant morbidity and mortality in immunocompromised patients, namely solid organ and hematopoietic cell transplant recipients, and can induce congenital infection in neonates. There is currently an unmet need for new management and treatment strategies. Establishment of an anti-CMV immune response is critical in order to control CMV infection. The two main human T cells involved in HCMV-specific response are αβ and non-Vγ9Vδ2 T cells that belong to γδ T cell compartment. CMV-induced non-Vγ9Vδ2 T cells harbor a specific clonal expansion and a phenotypic signature, and display effector functions against CMV. So far, only two main molecular mechanisms underlying CMV sensing have been identified. Non-Vγ9Vδ2 T cells can be activated either by stress-induced surface expression of the γδT cell receptor (TCR) ligand annexin A2, or by a multimolecular stress signature composed of the γδTCR ligand endothelial protein C receptor and co-stimulatory signals such as the ICAM-1-LFA-1 axis. All this basic knowledge can be harnessed to improve the clinical management of CMV infection in at-risk patients. In particular, non-Vγ9Vδ2 T cell monitoring could help better stratify the risk of infection and move forward a personalized medicine. Moreover, recent advances in cell therapy protocols open the way for a non-Vγ9Vδ2 T cell therapy in immunocompromised patients.< Réduire

Mots clés en anglais

Cytomegalovirus Infections

Hematopoietic Stem Cell Transplantation

Humans

Immunocompromised Host

Receptors

Antigen

T-Cell

gamma-delta

T-Lymphocyte Subsets

URI

https://oskar-bordeaux.fr/handle/20.500.12278/123955

DOI

http://dx.doi.org/10.1111/imr.12922

Unités de recherche

ImmunoConcEpT - UMR 5164

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Understanding human γδ T cell biology toward a better management of cytomegalovirus infection.

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Résumé en anglais

Mots clés en anglais

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Unités de recherche