FYKE, William; PREMOLI, Marika; ECHEVERRY ALZATE, Victor; LOPEZ-MORENO, Jose A.; LEMAIRE-MAYO, Valerie; CRUSIO, Wilhelmus; MARSICANO, Giovanni; WOHR, Markus; PIETROPAOLO, Susanna

doi:10.1002/aur.2562

Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]

PREMOLI, Marika

ECHEVERRY ALZATE, Victor

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Ce document a été publié dans

Autism Research. 2021-09, vol. 14, n° 9, p. 1854-1872

Résumé en anglais

Clinical and preclinical findings have suggested a role of the endocannabinoid system (ECS) in the etiopathology of autism spectrum disorder (ASD). Previous mouse studies have investigated the role of ECS in several behavioral domains; however, none of them has performed an extensive assessment of social and communication behaviors, that is, the main core features of ASD. This study employed a mouse line lacking the primary endocannabinoid receptor (CB1r) and characterized ultrasonic communication and social interaction in CB1−/−, CB1+/−, and CB1+/+ males and females. Quantitative and qualitative alterations in ultrasonic vocalizations (USVs) were observed in CB1 null mice both during early development (i.e., between postnatal days 4 and 10), and at adulthood (i.e., at 3 months of age). Adult mutants also showed marked deficits in social interest in the three-chamber test and social investigation in the direct social interaction test. These behavioral alterations were mostly observed in both sexes and appeared more marked in CB1−/− than CB1+/− mutant mice. Importantly, the adult USV alterations could not be attributed to differences in anxiety or sensorimotor abilities, as assessed by the elevated plus maze and auditory startle tests. Our findings demonstrate the role of CB1r in social communication and behavior, supporting the use of the CB1 full knockout mouse in preclinical research on these ASD-relevant core domains.< Réduire

Mots clés en anglais

Cannabinoid receptor

Mouse models

Phenotype

Sex differences

Ultrasounds

URI

https://oskar-bordeaux.fr/handle/20.500.12278/123926

DOI

http://dx.doi.org/10.1002/aur.2562

Unités de recherche

Neurocentre Magendie - U1215

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Communication and social interaction in the cannabinoid-type 1 receptor null mouse: Implications for autism spectrum disorder

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Résumé en anglais

Mots clés en anglais

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