BENHAMOU. Y; BAUDEL, J. L.; WYNCKEL, A.; GALICIER, L.; AZOULAY, E.; PROVÔT, F.; PÈNE, F.; MIRA, J. P.; PRESNE, C.; POULLIN, P.; HALIMI, J. M.; RIVIERE, E.; KANOUNI, T.; SEQUIN, A.; MOUSSON, C.; SERVAIS, A.; BORDESSOULE, D.; PEREZ, P.; HAMIDOU, M.; CHAUVEAU, D.; VEYRADIER, A.; COPPO, P.

doi:10.1002/ajh.23997

Langue

Article de revue

Ce document a été publié dans

American Journal of Hematology. 2015-06, vol. 90(6), p. E127–129

Résumé en anglais

To the Editor: Thrombotic thrombocytopenic purpura (TTP) is a specific form of thrombotic microangiopathy (TMA) characterized by thrombocytopenia, erythrocyte fragmentation, and widespread microvascular thrombi responsible for multi-organ failure of variable severity [1]. Surprisingly, while a profound thrombocytopenia is a typical feature of the disease, severe hemorrhage is a rare cause of mortality. Nevertheless, in case of severe bleeding or when an invasive procedure is needed (i.e., catheter insertion, spinal puncture), platelets transfusion may be required, although sudden clinical deteriorations and fatalities suggestive of a worsening of TTP within few hours after a platelet transfusion were reported [2,3]. To date, controversies remain on the effect of platelet transfusions during TTP [4–6]. In light of the uncertain risk of platelet transfusions in TTP and the lack of recently published data, we retrospectively reviewed admission data of all TTP patients with a severe acquired ADAMTS13 deficiency (\textless10% of activity in normal plasma) enrolled in the French TMA Reference Centre registry, in order to better assess the risk of platelet transfusions at the acute phase of TTP. ...< Réduire

Mots clés

Article CLINIQUE

URI

https://oskar-bordeaux.fr/handle/20.500.12278/11497

DOI

http://dx.doi.org/10.1002/ajh.23997

Unités de recherche

Biologie des maladies cardiovasculaires (BMC) - UMR 1034

Accès réservé

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Are platelet transfusions harmful in acquired thrombotic thrombocytopenic purpura at the acute phase? Experience of the French thrombotic microangiopathies reference center.

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés

URI

DOI

Unités de recherche