RIVIÈRE, Étienne; VIALLARD, Jean-François; GUY, Alexandre; KILANI, Badr; VIEIRA-DIAS, Juliana; PONS, Anne C.; COUFFINHAL, Thierry; PELLEGRIN, Jean-Luc; JAMES, Chloé

doi:10.1111/bjh.13444

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BMC_BrJHaematol_2015_Rivière.pdf (934.3Kb)

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RIVIÈRE, Étienne
Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases

VIALLARD, Jean-François
Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases

GUY, Alexandre

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British Journal of Haematology. 2015-08, vol. 170, n° 3, p. 408–415

Resumen en inglés

Persistent or chronic immune thrombocytopenias (P/C-ITP) are acquired blood disorders lasting more than 3 months or 1 year, respectively. The pathogenesis of these disorders is thought to be immunological. We hypothesized that some patients with P/C-ITP might have an intrinsic megakaryopoiesis defect. We identified a group of P/C-ITP patients with acquired isolated mild thrombocytopenia (30-100 × 10(9) /l), undetectable anti-platelet antibodies, negative autoimmune investigations and no need for treatment. We examined in vitro megakaryocyte differentiation and compared these patients' results with those of acute-ITP patients and healthy controls. No difference in proliferation, ploidy or expression of surface markers was found. In contrast, P/C-ITP patients had significantly fewer proplatelet-forming megakaryocytes. This novel observation demonstrated that some patients diagnosed with P/C-ITP have an intrinsic megakaryopoiesis defect independent of the bone-marrow environment. Further investigations are needed to dissect mechanisms underlying this impaired proplatelet formation in these patients.< Leer menos

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