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Hydroxytyrosol decreases LPS- and α-synuclein-induced microglial activation in vitro

dc.rights.licenseopenen_US
dc.contributor.authorGALLARDO-FERNANDEZ, Marta
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorHORNEDO ORTEGA, Ruth
dc.contributor.authorALONSO-BELLIDO, Isabel M.
dc.contributor.authorRODRIGUEZ-GOMEZ, Jose A.
dc.contributor.authorTRONCOSO, Ana M.
dc.contributor.authorGARCIA-PARRILLA, M. Carmen
dc.contributor.authorVENERO, Jose L.
dc.contributor.authorESPINOSA-OLIVA, Ana M.
dc.contributor.authorPABLOS, Rocio M. De
dc.date.accessioned2020-10-14T20:14:19Z
dc.date.available2020-10-14T20:14:19Z
dc.date.issued2020
dc.identifier.issn2076-3921en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11372
dc.description.abstractEnNeuroinflammation is a common feature shared by neurodegenerative disorders, such as Parkinson's disease (PD), and seems to play a key role in their development and progression. Microglia cells, the principal orchestrators of neuroinflammation, can be polarized in different phenotypes, which means they are able to have anti-inflammatory, pro-inflammatory, or neurodegenerative effects. Increasing evidence supports that the traditional Mediterranean dietary pattern is related to the reduction of cognitive decline in neurodegenerative diseases. A considerable intake of plant foods, fish, and extra virgin olive oil (EVOO), as well as a moderate consumption of red wine, all characteristic of the Mediterranean diet (MD), are behind these effects. These foods are especially rich in polyphenols, being the most relevant in the MD hydroxytyrosol (HT) and their derivatives present in EVOO, which have demonstrated a wide array of biological activities. Here, we demonstrate that HT is able to reduce the inflammation induced by two different stimuli: lipopolysaccharide and α-synuclein. We also study the possible molecular mechanisms involved in the anti-inflammatory effect of HT, including the study of nuclear factor kappa B (NF-кB), mitogen-activated protein kinases (MAPKs), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and inflammasome. Our data support the use of HT to prevent the inflammation associated with PD and shed light into the relationship between MD and this neurological disorder.
dc.language.isoENen_US
dc.subject.enMapks
dc.subject.enMediterranean Diet
dc.subject.enHydroxytyrosol
dc.subject.enInflammasome
dc.subject.enLipopolysaccharide
dc.subject.enMicroglia
dc.subject.enΑ-Synuclein
dc.title.enHydroxytyrosol decreases LPS- and α-synuclein-induced microglial activation in vitro
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/antiox9010036en_US
dc.subject.halSciences du Vivant [q-bio]/Biologie végétaleen_US
dc.identifier.pubmed31906130en_US
bordeaux.journalAntioxidantsen_US
bordeaux.page1-18en_US
bordeaux.volume9en_US
bordeaux.hal.laboratoriesOenologie - EA 4577en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Antioxidants&rft.date=2020&rft.volume=9&rft.spage=1-18&rft.epage=1-18&rft.eissn=2076-3921&rft.issn=2076-3921&rft.au=GALLARDO-FERNANDEZ,%20Marta&HORNEDO%20ORTEGA,%20Ruth&ALONSO-BELLIDO,%20Isabel%20M.&RODRIGUEZ-GOMEZ,%20Jose%20A.&TRONCOSO,%20Ana%20M.&rft.genre=article


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