Show simple item record

dc.rights.licenseopenen_US
dc.contributor.authorCOVELO FERNANDEZ, Ana
dc.contributor.authorERASO-PICHOT, Abel
dc.contributor.authorFERNANDEZ-MONCADA, Ignacio
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorSERRAT, Roman
dc.contributor.authorMARSICANO, Giovanni
dc.date.accessioned2021-10-19T14:37:26Z
dc.date.available2021-10-19T14:37:26Z
dc.date.issued2021-09-01
dc.identifier.issn0028-3908en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112816
dc.description.abstractEnThe endocannabinoid system (ECS) is involved in a variety of brain functions, mainly through the activation of the type-1 cannabinoid receptors (CB1R). CB1R are highly expressed throughout the brain at different structural, cellular and subcellular locations and its activity and expression levels have a direct impact in synaptic activity and behavior. In the last few decades, astrocytes have arisen as active players of brain physiology through their participation in the tripartite synapse and through their metabolic interaction with neurons. Here, we discuss some of the mechanisms by which astroglial CB1R at different subcellular locations, regulate astrocyte calcium signals and have an impact on gliotransmission and metabolic regulation. In addition, we discuss evidence pointing at astrocytes as potential important sources of endocannabinoid synthesis and release. Thus, we summarize recent findings that add further complexity and establish that the ECS is a fundamental effector of astrocyte functions in the brain. This article is part of the special issue on ‘Cannabinoids'.
dc.description.sponsorshipDissection des mécanismes hypothalamiques impliqués dans la détection du statut nutritionnel et régulation de la prise alimentaire via les interactions entre mTORC1, les mélanocortines et les endocannabinoïdes.en_US
dc.description.sponsorshipReprésentation sensorielle lors d'états psychotiques - ANR-16-CE37-0010en_US
dc.description.sponsorshipRecepteurs aux cannabinoides dans le codage visuel corticalen_US
dc.description.sponsorshipRôle du récepteur aux cannabinoïdes de type 1 mitochondriale dans les circuits hypothalamiques et son interaction avec la voie mTORC1 dans l'obésité. - ANR-18-CE14-0029en_US
dc.description.sponsorshipBordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043en_US
dc.language.isoENen_US
dc.subject.enAstrocyte-neuron communication
dc.subject.enAstrocytes
dc.subject.enCalcium
dc.subject.enCannabinoid receptor 1
dc.subject.enMetabolism
dc.title.enCB1R-dependent regulation of astrocyte physiology and astrocyte-neuron interactions
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.neuropharm.2021.108678en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed34157362en_US
bordeaux.journalNeuropharmacologyen_US
bordeaux.volume195en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionINSERM
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDEuropean Research Councilen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
hal.identifierhal-03385993
hal.version1
hal.date.transferred2021-10-19T14:37:37Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuropharmacology&rft.date=2021-09-01&rft.volume=195&rft.eissn=0028-3908&rft.issn=0028-3908&rft.au=COVELO%20FERNANDEZ,%20Ana&ERASO-PICHOT,%20Abel&FERNANDEZ-MONCADA,%20Ignacio&SERRAT,%20Roman&MARSICANO,%20Giovanni&rft.genre=article


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record