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CB1R-dependent regulation of astrocyte physiology and astrocyte-neuron interactions
Language
EN
Article de revue
This item was published in
Neuropharmacology. 2021-09-01, vol. 195
English Abstract
The endocannabinoid system (ECS) is involved in a variety of brain functions, mainly through the activation of the type-1 cannabinoid receptors (CB1R). CB1R are highly expressed throughout the brain at different structural, ...Read more >
The endocannabinoid system (ECS) is involved in a variety of brain functions, mainly through the activation of the type-1 cannabinoid receptors (CB1R). CB1R are highly expressed throughout the brain at different structural, cellular and subcellular locations and its activity and expression levels have a direct impact in synaptic activity and behavior. In the last few decades, astrocytes have arisen as active players of brain physiology through their participation in the tripartite synapse and through their metabolic interaction with neurons. Here, we discuss some of the mechanisms by which astroglial CB1R at different subcellular locations, regulate astrocyte calcium signals and have an impact on gliotransmission and metabolic regulation. In addition, we discuss evidence pointing at astrocytes as potential important sources of endocannabinoid synthesis and release. Thus, we summarize recent findings that add further complexity and establish that the ECS is a fundamental effector of astrocyte functions in the brain.
This article is part of the special issue on ‘Cannabinoids'.Read less <
English Keywords
Astrocyte-neuron communication
Astrocytes
Calcium
Cannabinoid receptor 1
Metabolism
ANR Project
Dissection des mécanismes hypothalamiques impliqués dans la détection du statut nutritionnel et régulation de la prise alimentaire via les interactions entre mTORC1, les mélanocortines et les endocannabinoïdes. - ANR-13-BSV4-0006
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Rôle du récepteur aux cannabinoïdes de type 1 mitochondriale dans les circuits hypothalamiques et son interaction avec la voie mTORC1 dans l'obésité.
Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043
Représentation sensorielle lors d'états psychotiques
Recepteurs aux cannabinoides dans le codage visuel cortical
Rôle du récepteur aux cannabinoïdes de type 1 mitochondriale dans les circuits hypothalamiques et son interaction avec la voie mTORC1 dans l'obésité.
Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043