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Retinoic acid increases glucocorticoid receptor phosphorylation via cyclin-dependent kinase 5.

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBROSSAUD, Julie
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorROUMES, Helene
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorHELBLING, Jean Christophe
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMOISAN, Marie Pierre
IDREF: 060242264
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorPALLET, Veronique
ORCID: 0000-0002-9078-3269
IDREF: 066841763
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFERREIRA, Guillaume
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBIYONG, Essi-Fanny
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorREDONNET, Anabelle
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCORCUFF, Jean-Benoit
IDREF: 058708154
dc.date.accessioned2021-09-28T09:55:37Z
dc.date.available2021-09-28T09:55:37Z
dc.date.issued2017
dc.identifier.issn1044-7431en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112460
dc.description.abstractEnGlucocorticoid receptor (GR) function is modulated by phosphorylation. As retinoic acid (RA) can activate some cytoplasmic kinases able to phosphorylate GR, we investigated whether RA could modulate GR phosphorylation in neuronal cells in a context of long-term glucocorticoid exposure. A 4-day treatment of dexamethasone (Dex) plus RA, showed that RA potentiated the (Dex)-induced phosphorylation on GR Serine 220 (pSer220GR) in the nucleus of a hippocampal HT22 cell line. This treatment increased the cytoplasmic ratio of p35/p25 proteins, which are major CDK5 cofactors. Roscovitine, a pharmacological CDK5 inhibitor, or a siRNA against CDK5 prevented RA potentiation of GR phosphorylation. Furthermore, roscovitine counter-acted the effect of RA on GR sensitive target proteins such as BDNF or tissue-transglutaminase. These data help understanding the interaction between RA- and glucocorticoid-signalling pathways, both of which have strong influences on the adult brain.
dc.language.isoENen_US
dc.subject.enRetinoic acid
dc.subject.enGlucocorticoid receptor
dc.subject.enPhosphorylation
dc.subject.enCyclin-dependent kinase 5
dc.subject.enHippocampus
dc.subject.enNeuron
dc.title.enRetinoic acid increases glucocorticoid receptor phosphorylation via cyclin-dependent kinase 5.
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.mcn.2017.05.001en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed28477983en_US
bordeaux.journalMolecular and Cellular Neuroscienceen_US
bordeaux.page96-104en_US
bordeaux.volume82en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.teamNutrition, mémoire et glucocorticoïdesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDUniversité de Bordeauxen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecular%20and%20Cellular%20Neuroscience&rft.date=2017&rft.volume=82&rft.spage=96-104&rft.epage=96-104&rft.eissn=1044-7431&rft.issn=1044-7431&rft.au=BROSSAUD,%20Julie&ROUMES,%20Helene&HELBLING,%20Jean%20Christophe&MOISAN,%20Marie%20Pierre&PALLET,%20Veronique&rft.genre=article


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