Postprandial hyperglycemia stimulates neuroglial plasticity in hypothalamic POMC neurons after a balanced meal
| dc.rights.license | open | en_US |
| dc.contributor.author | NUZZACI, Danae | |
| dc.contributor.author | CANSELL, Celine | |
| dc.contributor.author | LIENARD, Fabienne | |
| dc.contributor.author | NEDELEC, Emmanuelle | |
| dc.contributor.author | BEN FRADJ, Selma | |
| dc.contributor.author | CASTEL, Julien | |
| dc.contributor.author | FOPPEN, Ewout | |
| dc.contributor.author | DENIS, Raphael G. P. | |
| dc.contributor.author | GROUSELLE, Dominique | |
| dc.contributor.author | LADERRIERE, Amelie | |
| dc.contributor.author | LEMOINE, Aleth | |
| dc.contributor.author | MATHOU, Alexia | |
| dc.contributor.author | TOLLE, Virginie | |
| dc.contributor.author | HEURTAUX, Tony | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | FIORAMONTI, Xavier | |
| dc.contributor.author | AUDINAT, Etienne | |
| dc.contributor.author | PENICAUD, Luc | |
| dc.contributor.author | NAHON, Jean-Louis | |
| dc.contributor.author | ROVERE, Carole | |
| dc.contributor.author | BENANI, Alexandre | |
| dc.date.accessioned | 2021-09-24T13:35:14Z | |
| dc.date.available | 2021-09-24T13:35:14Z | |
| dc.date.issued | 2020-03 | |
| dc.identifier.issn | 2211-1247 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112387 | |
| dc.description.abstractEn | Mechanistic studies in rodents evidenced synaptic remodeling in neuronal circuits that control food intake. However, the physiological relevance of this process is not well defined. Here, we show that the firing activity of anorexigenic POMC neurons located in the hypothalamus is increased after a standard meal. Postprandial hyperactivity of POMC neurons relies on synaptic plasticity that engages pre-synaptic mechanisms, which does not involve structural remodeling of synapses but retraction of glial coverage. These functional and morphological neuroglial changes are triggered by postprandial hyperglycemia. Chemogenetically induced glial retraction on POMC neurons is sufficient to increase POMC activity and modify meal patterns. These findings indicate that synaptic plasticity within the melanocortin system happens at the timescale of meals and likely contributes to short-term control of food intake. Interestingly, these effects are lost with a high-fat meal, suggesting that neuroglial plasticity of POMC neurons is involved in the satietogenic properties of foods. | |
| dc.description.sponsorship | Contrôle nerveux de la prise alimentaire et du métabolisme par une molécule neurale d'adhésion cellulaire | en_US |
| dc.description.sponsorship | ISITE " BFC | en_US |
| dc.description.sponsorship | Réseau d'Innovation sur les Voies de Signalisation en Sciences de la Vie - ANR-11-LABX-0028 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Hypothalamus | |
| dc.subject.en | Plasticity | |
| dc.subject.en | Energy homeostasis | |
| dc.subject.en | Obesity | |
| dc.subject.en | Melanocortin system | |
| dc.subject.en | Pro-opiomelanocortin neurons | |
| dc.subject.en | Astrocytes | |
| dc.subject.en | Food intake | |
| dc.subject.en | Satiety | |
| dc.title.en | Postprandial hyperglycemia stimulates neuroglial plasticity in hypothalamic POMC neurons after a balanced meal | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.celrep.2020.02.029 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 32130907 | en_US |
| bordeaux.journal | Cell Reports | en_US |
| bordeaux.page | 3067-3078.e5 | en_US |
| bordeaux.volume | 30 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 9 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| bordeaux.identifier.funderID | Conseil régional de Bourgogne-Franche-Comté | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20Reports&rft.date=2020-03&rft.volume=30&rft.issue=9&rft.spage=3067-3078.e5&rft.epage=3067-3078.e5&rft.eissn=2211-1247&rft.issn=2211-1247&rft.au=NUZZACI,%20Danae&CANSELL,%20Celine&LIENARD,%20Fabienne&NEDELEC,%20Emmanuelle&BEN%20FRADJ,%20Selma&rft.genre=article |
