PUFA and their derivatives in neurotransmission and synapses: a new hallmark of synaptopathies
| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DI MICELI, Mathieu | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | BOSCH BOUJU, Clementine
ORCID: 0000-0001-8869-768X IDREF: 156530244 | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LAYE, Sophie
ORCID: 0000-0002-3843-1012 IDREF: 11366883X | |
| dc.date.accessioned | 2021-09-22T14:20:17Z | |
| dc.date.available | 2021-09-22T14:20:17Z | |
| dc.date.issued | 2020-11 | |
| dc.identifier.issn | 0029-6651 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112333 | |
| dc.description.abstractEn | PUFA of the n-3 and n-6 families are present in high concentration in the brain where they are major components of cell membranes. The main forms found in the brain are DHA (22 :6, n-3) and arachidonic acid (20:4, n-6). In the past century, several studies pinpointed that modifications of n-3 and n-6 PUFA levels in the brain through dietary supply or genetic means are linked to the alterations of synaptic function. Yet, synaptopathies emerge as a common characteristic of neurodevelopmental disorders, neuropsychiatric diseases and some neurodegenerative diseases. Understanding the mechanisms of action underlying the activity of PUFA at the level of synapses is thus of high interest. In this frame, dietary supplementation in PUFA aiming at restoring or promoting the optimal function of synapses appears as a promising strategy to treat synaptopathies. This paper reviews the link between dietary PUFA, synapse formation and the role of PUFA and their metabolites in synaptic functions. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Synaptic plasticity | |
| dc.subject.en | DHA | |
| dc.subject.en | EPA | |
| dc.subject.en | Endocannabinoids | |
| dc.subject.en | Oxylipins | |
| dc.subject.en | Anandamide | |
| dc.subject.en | Arachidonic acid | |
| dc.subject.en | Cannabinoid receptor 1 | |
| dc.subject.en | Cannabinoid receptor 2 | |
| dc.subject.en | Cyclooxygenase 1. 2 | |
| dc.subject.en | N-docosahexaenoylethanolamide | |
| dc.subject.en | Endocannabinoids | |
| dc.subject.en | Y aminobutyric acid | |
| dc.subject.en | G protein-coupled receptor | |
| dc.subject.en | Linoleic acid | |
| dc.subject.en | Long-chain | |
| dc.subject.en | Long-term depression | |
| dc.subject.en | Long-term potentiation | |
| dc.subject.en | Platelet-activating factor | |
| dc.subject.en | Phospholipase A2 | |
| dc.title.en | PUFA and their derivatives in neurotransmission and synapses: a new hallmark of synaptopathies | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1017/S0029665120000129 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 32299516 | en_US |
| bordeaux.journal | Proceedings of the Nutrition Society | en_US |
| bordeaux.page | 388-403 | en_US |
| bordeaux.volume | 79 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
| bordeaux.team | Nutrition, mémoire et glucocorticoïdes | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Proceedings%20of%20the%20Nutrition%20Society&rft.date=2020-11&rft.volume=79&rft.issue=4&rft.spage=388-403&rft.epage=388-403&rft.eissn=0029-6651&rft.issn=0029-6651&rft.au=DI%20MICELI,%20Mathieu&BOSCH%20BOUJU,%20Clementine&LAYE,%20Sophie&rft.genre=article |
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