Circulating triglycerides gate dopamine-associated behaviors through DRD2-expressing neurons
dc.rights.license | open | en_US |
dc.contributor.author | BERLAND, Chloe | |
dc.contributor.author | MONTALBAN, Enrica | |
dc.contributor.author | PERRIN, Elodie | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | DI MICELI, Mathieu | |
dc.contributor.author | NAKAMURA, Yuko | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | MARTINAT, Maud | |
dc.contributor.author | SULLIVAN, Mary | |
dc.contributor.author | DAVIS, Xue | |
dc.contributor.author | SHENASA, Mohammad Ali | |
dc.contributor.author | MARTIN, Claire | |
dc.contributor.author | TOLU, Stefania | |
dc.contributor.author | MARTI, Fabio | |
hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
dc.contributor.author | CAILLE GARNIER, Stéphanie | |
dc.contributor.author | CASTEL, Julien | |
dc.contributor.author | PEREZ, Sylvie | |
dc.contributor.author | SALINAS, Casper Gravesen | |
dc.contributor.author | MOREL, Chloe
IDREF: 257498346 | |
dc.contributor.author | HECKSHER-SORENSEN, Jacob | |
hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
dc.contributor.author | CADOR, Martine | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | FIORAMONTI, Xavier | |
dc.contributor.author | TSCHOP, Matthias | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | LAYE, Sophie | |
dc.contributor.author | VENANCE, Laurent | |
dc.contributor.author | FAURE, Philippe | |
dc.contributor.author | HNASKO, Thomas | |
dc.contributor.author | SMALL, Dana | |
dc.contributor.author | GANGAROSSA, Giuseppe | |
dc.contributor.author | LUQUET, Serge | |
dc.date.accessioned | 2021-09-22T13:57:10Z | |
dc.date.available | 2021-09-22T13:57:10Z | |
dc.date.issued | 2020-04 | |
dc.identifier.issn | 1550-4131 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112330 | |
dc.description.abstractEn | Energy-dense food alters dopaminergic (DA) transmission in the mesocorticolimbic (MCL) system and can promote reward dysfunctions, compulsive feeding, and weight gain. Yet the mechanisms by which nutrients influence the MCL circuitry remain elusive. Here, we show that nutritional triglycerides (TGs), a conserved post-prandial metabolic signature among mammals, can be metabolized within the MCL system and modulate DA-associated behaviors by gating the activity of dopamine receptor subtype 2 (DRD2)-expressing neurons through a mechanism that involves the action of the lipoprotein lipase (LPL). Further, we show that in humans, postprandial TG excursions modulate brain responses to food cues in individuals carrying a genetic risk for reduced DRD2 signaling. Collectively, these findings unveil a novel mechanism by which dietary TGs directly alter signaling in the reward circuit to regulate behavior, thereby providing a new mechanistic basis by which energy-rich diets may lead to (mal)adaptations in DA signaling that underlie reward deficit and compulsive behavior. | |
dc.description.sponsorship | Rôle de la lipoprotéine lipase dans le contrôle nerveux de la balance énergétique | en_US |
dc.description.sponsorship | Le métabolisme des lipides dans le cerveau est un regulateur essentiel de l'homéostasie énergétique - ANR-16-CE14-0026 | en_US |
dc.language.iso | EN | en_US |
dc.subject | Comportement alimentaire | |
dc.subject | Santé humaine | |
dc.title.en | Circulating triglycerides gate dopamine-associated behaviors through DRD2-expressing neurons | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1016/j.cmet.2020.02.010 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
dc.identifier.pubmed | 32142669 | en_US |
bordeaux.journal | Cell Metabolism | en_US |
bordeaux.page | 773-790 | en_US |
bordeaux.volume | 31 | en_US |
bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
bordeaux.issue | 4 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INRAE | en_US |
bordeaux.institution | CNRS | |
bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | Centre National de la Recherche Scientifique | en_US |
bordeaux.identifier.funderID | Bayerische Forschungsstiftung | en_US |
bordeaux.identifier.funderID | Allen Foundation | en_US |
bordeaux.identifier.funderID | Nutricia Research Foundation | en_US |
bordeaux.identifier.funderID | Groupe Lipides et Nutrition | en_US |
bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
hal.export | false | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20Metabolism&rft.date=2020-04&rft.volume=31&rft.issue=4&rft.spage=773-790&rft.epage=773-790&rft.eissn=1550-4131&rft.issn=1550-4131&rft.au=BERLAND,%20Chloe&MONTALBAN,%20Enrica&PERRIN,%20Elodie&DI%20MICELI,%20Mathieu&NAKAMURA,%20Yuko&rft.genre=article |
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