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Circulating triglycerides gate dopamine-associated behaviors through DRD2-expressing neurons

dc.rights.licenseopenen_US
dc.contributor.authorBERLAND, Chloe
dc.contributor.authorMONTALBAN, Enrica
dc.contributor.authorPERRIN, Elodie
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDI MICELI, Mathieu
dc.contributor.authorNAKAMURA, Yuko
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMARTINAT, Maud
dc.contributor.authorSULLIVAN, Mary
dc.contributor.authorDAVIS, Xue
dc.contributor.authorSHENASA, Mohammad Ali
dc.contributor.authorMARTIN, Claire
dc.contributor.authorTOLU, Stefania
dc.contributor.authorMARTI, Fabio
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCAILLE GARNIER, Stéphanie
dc.contributor.authorCASTEL, Julien
dc.contributor.authorPEREZ, Sylvie
dc.contributor.authorSALINAS, Casper Gravesen
dc.contributor.authorMOREL, Chloe
dc.contributor.authorHECKSHER-SORENSEN, Jacob
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCADOR, Martine
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFIORAMONTI, Xavier
dc.contributor.authorTSCHOP, Matthias
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
ORCID: 0000-0002-3843-1012
IDREF: 11366883X
dc.contributor.authorVENANCE, Laurent
dc.contributor.authorFAURE, Philippe
dc.contributor.authorHNASKO, Thomas
dc.contributor.authorSMALL, Dana
dc.contributor.authorGANGAROSSA, Giuseppe
dc.contributor.authorLUQUET, Serge
dc.date.accessioned2021-09-22T13:57:10Z
dc.date.available2021-09-22T13:57:10Z
dc.date.issued2020-04
dc.identifier.issn1550-4131en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112330
dc.description.abstractEnEnergy-dense food alters dopaminergic (DA) transmission in the mesocorticolimbic (MCL) system and can promote reward dysfunctions, compulsive feeding, and weight gain. Yet the mechanisms by which nutrients influence the MCL circuitry remain elusive. Here, we show that nutritional triglycerides (TGs), a conserved post-prandial metabolic signature among mammals, can be metabolized within the MCL system and modulate DA-associated behaviors by gating the activity of dopamine receptor subtype 2 (DRD2)-expressing neurons through a mechanism that involves the action of the lipoprotein lipase (LPL). Further, we show that in humans, postprandial TG excursions modulate brain responses to food cues in individuals carrying a genetic risk for reduced DRD2 signaling. Collectively, these findings unveil a novel mechanism by which dietary TGs directly alter signaling in the reward circuit to regulate behavior, thereby providing a new mechanistic basis by which energy-rich diets may lead to (mal)adaptations in DA signaling that underlie reward deficit and compulsive behavior.
dc.description.sponsorshipRôle de la lipoprotéine lipase dans le contrôle nerveux de la balance énergétiqueen_US
dc.description.sponsorshipLe métabolisme des lipides dans le cerveau est un regulateur essentiel de l'homéostasie énergétique - ANR-16-CE14-0026en_US
dc.language.isoENen_US
dc.subjectComportement alimentaire
dc.subjectSanté humaine
dc.title.enCirculating triglycerides gate dopamine-associated behaviors through DRD2-expressing neurons
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.cmet.2020.02.010en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed32142669en_US
bordeaux.journalCell Metabolismen_US
bordeaux.page773-790en_US
bordeaux.volume31en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionCNRS
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDCentre National de la Recherche Scientifiqueen_US
bordeaux.identifier.funderIDBayerische Forschungsstiftungen_US
bordeaux.identifier.funderIDAllen Foundationen_US
bordeaux.identifier.funderIDNutricia Research Foundationen_US
bordeaux.identifier.funderIDGroupe Lipides et Nutritionen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20Metabolism&rft.date=2020-04&rft.volume=31&rft.issue=4&rft.spage=773-790&rft.epage=773-790&rft.eissn=1550-4131&rft.issn=1550-4131&rft.au=BERLAND,%20Chloe&MONTALBAN,%20Enrica&PERRIN,%20Elodie&DI%20MICELI,%20Mathieu&NAKAMURA,%20Yuko&rft.genre=article


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