Show simple item record

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGALERA, Cedric
ORCID: 0000-0003-0549-9608
IDREF: 110034007
dc.contributor.authorBARBOSA, Susana
dc.contributor.authorCOLLET, Ophelie
dc.contributor.authorKHALFALLAH, Olfa
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSUTTER-DALLAY, Anne-Laure
dc.contributor.authorKOEHL, Muriel
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCAPURON, Lucile
dc.contributor.authorVAN DER WAERDEN, Judith
dc.contributor.authorMELCHIOR, Maria
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOTE, Sylvana
dc.contributor.authorHEUDE, Barbara
dc.contributor.authorGLAICHENHAUS, Nicolas
dc.contributor.authorDAVIDOVIC, Laetitia
dc.date.accessioned2021-09-21T13:07:30Z
dc.date.available2021-09-21T13:07:30Z
dc.date.issued2021-03-15
dc.identifier.issn0006-3223en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/112295
dc.description.abstractEnBackground: Recent research suggests that immune dysregulation in pregnancy could be a risk factor for anxiety and depression symptoms in offspring. Whereas animal studies have demonstrated the importance of the link between perinatal cytokines and abnormal behaviors in offspring, human epidemiological studies in this area remain limited. The objectives of the study were to describe the network of cord serum cytokines at birth and test whether they are associated with subsequent anxiety and depression symptom trajectories in offspring. Methods: We used data and biological samples from 871 mother–child pairs followed up from pregnancy to 8 years of age and participating in the French mother–child cohort EDEN (a study on the pre- and early postnatal determinants of child health and development). Cord serum cytokines were measured at birth. Children’s symptoms of anxiety and depression were assessed with the emotional difficulties subscore of the Strength and Difficulties Questionnaire at ages 3, 5, and 8 years, from which trajectories of anxiety-depression symptoms were derived. Results: Results showed a significant association between cord serum interleukin-7 at birth and the trajectories of children’s anxiety-depression symptoms between ages 3 to 8 years (adjusted odds ratio, 0.73; 95% confidence interval, 0.57–0.93). The associations considered relevant confounders, including prenatal maternal depressive symptoms. Conclusions Early immune changes may contribute to subsequent anxiety and depression symptoms in childhood. Beyond the understanding of mechanisms underlying the occurrence of emotional difficulties in children, our findings open avenues for future research in human and animals.
dc.description.sponsorshipDéterminants sociaux des troubles psychologiques et des apprentissages chez les enfants d'âge scolaireen_US
dc.language.isoENen_US
dc.subjectBiostatistics
dc.subjectBirth cohort
dc.subjectEpidemiology
dc.subjectImmunology
dc.subject.enAnxiety/depression
dc.subject.enCord cytokines
dc.title.enCord Serum Cytokines at Birth and Children's Anxiety-Depression Trajectories From 3 to 8 Years: The EDEN Mother-Child Cohort
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.biopsych.2020.10.009en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed33349450en_US
bordeaux.journalBiological Psychiatryen_US
bordeaux.page541-549en_US
bordeaux.volume89en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionINSERM
bordeaux.teamPsychoneuroimmunologie et Nutrition: Approches expérimentales et cliniquesen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.teamPharmacoEpi-Drugsen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation de Franceen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDMinistère de l'Enseignement supérieur, de la Recherche et de l'Innovationen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDAgence Française de Sécurité Sanitaire de l'Environnement et du Travailen_US
bordeaux.identifier.funderIDInstitut de Veille Sanitaireen_US
bordeaux.identifier.funderIDUniversité Paris-Suden_US
bordeaux.identifier.funderIDInstitut National de Prévention et d'Éducation pour la Santéen_US
bordeaux.identifier.funderIDMutuelle Générale de l'Education Nationaleen_US
bordeaux.identifier.funderIDSociété Francophone du Diabèteen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDInstitut pour la Recherche en Santé Publiqueen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biological%20Psychiatry&rft.date=2021-03-15&rft.volume=89&rft.issue=6&rft.spage=541-549&rft.epage=541-549&rft.eissn=0006-3223&rft.issn=0006-3223&rft.au=GALERA,%20Cedric&BARBOSA,%20Susana&COLLET,%20Ophelie&KHALFALLAH,%20Olfa&AOUIZERATE,%20Bruno&rft.genre=article


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record