Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain
dc.rights.license | open | en_US |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | MADORE, Charlotte | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | LEYROLLE, Quentin | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | MOREL, Lydie | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | GREENHALGH, Andrew D. | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | LACABANNE, Chloe | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | BOSCH BOUJU, Clementine | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | BOUREL, Julien | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | THOMAZEAU, Aurore | |
dc.contributor.author | HOPPERTON, K. E. | |
dc.contributor.author | BECCARI, Sol | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | SERE, Alexandra | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | AUBERT, Agnes | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | DE SMEDT-PEYRUSSE, Veronique | |
dc.contributor.author | LECOURS, C. | |
dc.contributor.author | BISHT, K. | |
dc.contributor.author | FOURGEAUD, L. | |
dc.contributor.author | GREGOIRE, S. | |
dc.contributor.author | BRETILLON, Lionel | |
dc.contributor.author | GRANT, N. J. | |
dc.contributor.author | BADAUT, Jerome | |
dc.contributor.author | GRESSENS, P. | |
dc.contributor.author | SIERRA, A. | |
dc.contributor.author | BUTOVSKY, O. | |
dc.contributor.author | TREMBLAY, Marie-Eve | |
dc.contributor.author | BAZINET, Richard P. | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | JOFFRE, Corinne | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | NADJAR, Agnes | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | LAYE, Sophie
ORCID: 0000-0002-3843-1012 IDREF: 11366883X | |
dc.date.accessioned | 2021-09-09T13:13:02Z | |
dc.date.available | 2021-09-09T13:13:02Z | |
dc.date.issued | 2021 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/112192 | |
dc.description.abstractEn | Omega-3 fatty acids (n-3 polyunsaturated fatty acids; n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary intake of n-3 PUFAs. Low maternal intake of n-3 PUFAs has been linked to neurodevelopmental diseases in epidemiological studies, but the mechanisms by which a n-3 PUFA dietary imbalance affects CNS development are poorly understood. Active microglial engulfment of synaptic elements is an important process for normal brain development and altered synapse refinement is a hallmark of several neurodevelopmental disorders. Here, we identify a molecular mechanism for detrimental effects of low maternal n-3 PUFA intake on hippocampal development. Our results show that maternal dietary n-3 PUFA deficiency increases microglial phagocytosis of synaptic elements in the developing hippocampus, through the activation of 12/15- lipoxygenase (LOX)/12-HETE signaling, which alters neuronal morphology and affects cognition in the postnatal offspring. While women of child bearing age are at higher risk of dietary n-3 PUFA deficiency, these findings provide new insights into the mechanisms linking maternal nutrition to neurodevelopmental disorders.One Sentence SummaryLow maternal omega-3 fatty acids intake impairs microglia-mediated synaptic refinement via 12-HETE pathway in the developing brain. | |
dc.language.iso | EN | en_US |
dc.title.en | Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain | |
dc.type | Document de travail - Pré-publication | en_US |
dc.identifier.doi | 10.1101/744136 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INRAE | en_US |
bordeaux.team | Psychoneuroimmunologie et Nutrition: Approches expérimentales et cliniques | en_US |
hal.identifier | hal-03339536 | |
hal.version | 1 | |
hal.date.transferred | 2021-09-09T13:13:13Z | |
hal.export | true | |
workflow.import.source | dissemin | |
dc.rights.cc | CC BY-NC-ND | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2021&rft.au=MADORE,%20Charlotte&LEYROLLE,%20Quentin&MOREL,%20Lydie&GREENHALGH,%20Andrew%20D.&LACABANNE,%20Chloe&rft.genre=preprint |