Dairy fat blend improves brain DHA and neuroplasticity and regulates corticosterone in mice
| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DINEL, Anne Laure
ORCID: 0000-0002-8668-9413 IDREF: 131872109 | |
| dc.contributor.author | REY, C. | |
| dc.contributor.author | BONHOMME, C. | |
| dc.contributor.author | LE RUYET, P. | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | JOFFRE, Corinne | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LAYE, Sophie
ORCID: 0000-0002-3843-1012 IDREF: 11366883X | |
| dc.date.accessioned | 2021-08-27T07:27:09Z | |
| dc.date.available | 2021-08-27T07:27:09Z | |
| dc.date.issued | 2016-06-01 | |
| dc.identifier.issn | 0952-3278 | en_US |
| dc.identifier.uri | https://www.researchgate.net/publication/301756991_Dairy_fat_blend_improves_brain_DHA_and_neuroplasticity_and_regulates_corticosterone_in_mice | |
| dc.identifier.uri | oai:crossref.org:10.1016/j.plefa.2016.03.013 | |
| dc.identifier.uri | oai:researchgate.net:301756991 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/110224 | |
| dc.description.abstractEn | Mimicking the breast milk lipid composition appears to be necessary for infant formula to cover the brain’s needs in n-3 PUFA. In this study, we evaluated the impact of partial replacement of vegetable oil (VL) in infant formula by dairy fat (DL) on docosahexaenoic acid (DHA) brain level, neuroplasticity and corticosterone in mice. Mice were fed with balanced VL or balanced DL diets enriched or not in DHA and arachidonic acid (ARA) from the first day of gestation. Brain DHA level, microglia number, neurogenesis, corticosterone and glucocorticoid receptor expression were measured in the offsprings. DL diet increased DHA and neuroplasticity in the brain of mice at postnatal day (PND) 14 and at adulthood compared to VL. At PND14, ARA and DHA supplementation increased DHA in VL but not in DL mice brain. Importantly, DHA and ARA supplementation further improved neurogenesis and decreased corticosterone level in DL mice at adulthood. In conclusion, dairy lipids improve brain DHA level and neuroplasticity. | |
| dc.language.iso | EN | en_US |
| dc.source | crossref | |
| dc.source | researchgate | |
| dc.subject.en | Dairy lipid | |
| dc.subject.en | DHA | |
| dc.subject.en | Microglia | |
| dc.subject.en | Neurogenesis | |
| dc.subject.en | HPA axis | |
| dc.subject.en | PUFA | |
| dc.title.en | Dairy fat blend improves brain DHA and neuroplasticity and regulates corticosterone in mice | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.plefa.2016.03.013 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 27269711 | en_US |
| bordeaux.journal | Prostaglandins, Leukotrienes and Essential Fatty Acids | en_US |
| bordeaux.page | 29-38 | en_US |
| bordeaux.volume | 109 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | dissemin | |
| hal.export | false | |
| workflow.import.source | dissemin | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Prostaglandins,%20Leukotrienes%20and%20Essential%20Fatty%20Acids&rft.date=2016-06-01&rft.volume=109&rft.spage=29-38&rft.epage=29-38&rft.eissn=0952-3278&rft.issn=0952-3278&rft.au=DINEL,%20Anne%20Laure&REY,%20C.&BONHOMME,%20C.&LE%20RUYET,%20P.&JOFFRE,%20Corinne&rft.genre=article |
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