DINEL, Anne Laure; REY, C.; BONHOMME, C.; LE RUYET, P.; JOFFRE, Corinne; LAYE, Sophie

doi:10.1016/j.plefa.2016.03.013

Métadonnées

Afficher la notice complète

Licence d’utilisation du document

DINEL, Anne Laure

Nutrition et Neurobiologie intégrée [NutriNeuro]

REY, C.

BONHOMME, C.

Langue

Article de revue

Ce document a été publié dans

Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-06-01, vol. 109, p. 29-38

Résumé en anglais

Mimicking the breast milk lipid composition appears to be necessary for infant formula to cover the brain’s needs in n-3 PUFA. In this study, we evaluated the impact of partial replacement of vegetable oil (VL) in infant formula by dairy fat (DL) on docosahexaenoic acid (DHA) brain level, neuroplasticity and corticosterone in mice. Mice were fed with balanced VL or balanced DL diets enriched or not in DHA and arachidonic acid (ARA) from the first day of gestation. Brain DHA level, microglia number, neurogenesis, corticosterone and glucocorticoid receptor expression were measured in the offsprings. DL diet increased DHA and neuroplasticity in the brain of mice at postnatal day (PND) 14 and at adulthood compared to VL. At PND14, ARA and DHA supplementation increased DHA in VL but not in DL mice brain. Importantly, DHA and ARA supplementation further improved neurogenesis and decreased corticosterone level in DL mice at adulthood. In conclusion, dairy lipids improve brain DHA level and neuroplasticity.< Réduire

Mots clés en anglais

Dairy lipid

DHA

Microglia

Neurogenesis

HPA axis

PUFA

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Dairy fat blend improves brain DHA and neuroplasticity and regulates corticosterone in mice

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche