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A Cell-Penetrating Foldamer with a Bioreducible Linkage for Intracellular Delivery of DNA

dc.contributor.authorDOUAT, Celine
dc.contributor.authorAISENBREY, Christopher
dc.contributor.authorANTUNES, Stephanie
dc.contributor.authorDECOSSAS, Marion
dc.contributor.authorLAMBERT, Olivier
dc.contributor.authorBECHINGER, Burkhard
dc.contributor.authorKICHLER, Antoine
dc.contributor.authorGUICHARD, Gilles
IDREF: 084339268
dc.date.accessioned2020-09-03T08:02:12Z
dc.date.available2020-09-03T08:02:12Z
dc.date.issued2015
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10988
dc.description.abstractEnDespite significant advances in foldamer chemistry, tailored delivery systems based on foldamer architectures, which provide a high level of control over secondary structure, are curiously rare among non-viral technologies for transporting nucleic acids into cells. A potent pH-responsive, bioreducible cell-penetrating foldamer (CPF) was developed through covalent dimerization of a short (8-mer) amphipathic oligourea sequence bearing histidine-type units. This CPF exhibits a high capacity to assemble with pDNA and mediates efficient delivery of nucleic acids into the cell. Furthermore, it does not adversely affect cellular viability and was shown to compare favorably with a cognate peptide transfection agent based on His-rich sequences.
dc.language.isoen
dc.title.enA Cell-Penetrating Foldamer with a Bioreducible Linkage for Intracellular Delivery of DNA
dc.typeArticle de revue
dc.identifier.doi10.1002/anie.201504884
dc.subject.halChimie/Matériaux
bordeaux.journalAngewandte Chemie (International ed. in English)
bordeaux.page11133-7
bordeaux.volume54
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.issue38
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
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