A Cell-Penetrating Foldamer with a Bioreducible Linkage for Intracellular Delivery of DNA
dc.contributor.author | DOUAT, Celine | |
dc.contributor.author | AISENBREY, Christopher | |
dc.contributor.author | ANTUNES, Stephanie | |
dc.contributor.author | DECOSSAS, Marion | |
dc.contributor.author | LAMBERT, Olivier | |
dc.contributor.author | BECHINGER, Burkhard | |
dc.contributor.author | KICHLER, Antoine | |
dc.contributor.author | GUICHARD, Gilles
IDREF: 084339268 | |
dc.date.accessioned | 2020-09-03T08:02:12Z | |
dc.date.available | 2020-09-03T08:02:12Z | |
dc.date.issued | 2015 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/10988 | |
dc.description.abstractEn | Despite significant advances in foldamer chemistry, tailored delivery systems based on foldamer architectures, which provide a high level of control over secondary structure, are curiously rare among non-viral technologies for transporting nucleic acids into cells. A potent pH-responsive, bioreducible cell-penetrating foldamer (CPF) was developed through covalent dimerization of a short (8-mer) amphipathic oligourea sequence bearing histidine-type units. This CPF exhibits a high capacity to assemble with pDNA and mediates efficient delivery of nucleic acids into the cell. Furthermore, it does not adversely affect cellular viability and was shown to compare favorably with a cognate peptide transfection agent based on His-rich sequences. | |
dc.language.iso | en | |
dc.title.en | A Cell-Penetrating Foldamer with a Bioreducible Linkage for Intracellular Delivery of DNA | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1002/anie.201504884 | |
dc.subject.hal | Chimie/Matériaux | |
bordeaux.journal | Angewandte Chemie (International ed. in English) | |
bordeaux.page | 11133-7 | |
bordeaux.volume | 54 | |
bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248 | * |
bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248) | |
bordeaux.issue | 38 | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.institution | Bordeaux INP | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Angewandte%20Chemie%20(International%20ed.%20in%20English)&rft.date=2015&rft.volume=54&rft.issue=38&rft.spage=11133-7&rft.epage=11133-7&rft.au=DOUAT,%20Celine&AISENBREY,%20Christopher&ANTUNES,%20Stephanie&DECOSSAS,%20Marion&LAMBERT,%20Olivier&rft.genre=article |
Fichier(s) constituant ce document
Fichiers | Taille | Format | Vue |
---|---|---|---|
Il n'y a pas de fichiers associés à ce document. |