Synthesis, DFT and POM analyses of cytotoxicity activity of alpha-camidophosphonates derivatives: Identification of potential antiviral O,O-pharmacophore site
| dc.rights.license | open | en_US |
| dc.contributor.author | RACHEDI, K. O. | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | OUK, T. S. | |
| dc.contributor.author | BAHADI, R. | |
| dc.contributor.author | BOUZINA, A. | |
| dc.contributor.author | DJOUAD, S. E. | |
| dc.contributor.author | BECHLEM, K. | |
| dc.contributor.author | ZERROUKI, R. | |
| dc.contributor.author | BEN HADDA, T. | |
| dc.contributor.author | ALMALKI, F. | |
| dc.contributor.author | BERREDJEM, M. | |
| dc.date.accessioned | 2021-07-16T14:31:04Z | |
| dc.date.available | 2021-07-16T14:31:04Z | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 0022-2860 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/109294 | |
| dc.description.abstractEn | In the present study, we investigated the cytotoxic activity of three compounds prepared starting from amino acids. These derivatives were evaluated for their in vitro antitumor activity against human cell lines (PRI, K562 and JURKAT). Their cytotoxicity was also evaluated at different concentrations on several cell lines. On the other hand, DFT calculation has been used to analyze the electronic and geometric characteristics. The HOMO, LUMO and gap energies were also deduced for the stable structure for each compound. These results will be correlated with the experimental values. The bioinformatic POM (Petra/Osiris/Molinspiration) analyses of the relative cytotoxicity of these derivatives are reported in comparison to Chlorambucil. (C) 2019 Published by Elsevier B.V. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Amidophosphonate | |
| dc.subject.en | Cytotoxicity activity | |
| dc.subject.en | DFT calculations | |
| dc.subject.en | Descriptors | |
| dc.subject.en | POM analyses | |
| dc.title.en | Synthesis, DFT and POM analyses of cytotoxicity activity of alpha-camidophosphonates derivatives: Identification of potential antiviral O,O-pharmacophore site | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.molstruc.2019.07.053 | en_US |
| dc.subject.hal | Chimie/Matériaux | en_US |
| bordeaux.journal | Journal of Molecular Structure | en_US |
| bordeaux.page | 196-203 | en_US |
| bordeaux.volume | 1197 | en_US |
| bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03289141 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-07-16T14:31:07Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Molecular%20Structure&rft.date=2019&rft.volume=1197&rft.spage=196-203&rft.epage=196-203&rft.eissn=0022-2860&rft.issn=0022-2860&rft.au=RACHEDI,%20K.%20O.&OUK,%20T.%20S.&BAHADI,%20R.&BOUZINA,%20A.&DJOUAD,%20S.%20E.&rft.genre=article |
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