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dc.rights.licenseopenen_US
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorSEHL, Anthony
dc.contributor.authorCOUEDELO, Leslie
dc.contributor.authorCHAMEKH-COELHO, Ikram
dc.contributor.authorVAYSSE, Carole
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorCANSELL, Maud
dc.date.accessioned2021-07-16T14:29:34Z
dc.date.available2021-07-16T14:29:34Z
dc.date.issued2019
dc.identifier.issn0007-1145en_US
dc.identifier.otherhttps://doi.org/10.1017/S0007114519001491en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/109289
dc.description.abstractEnThe aim of this work was to study the bioavailability of fatty acids (FA), focusing on n-3 long-chain (LC) PUFA, carried by different molecular lipid species, that is, phospholipids (PL) or TAG, with three formulations based on fish oils or marine PL, providing a similar n-3 LC PUFA amount. The digestive lipolysis was first assessed using an in vitro enzymatic model. Then, intestinal absorption and enterocyte metabolism were investigated in vivo, on male Wistar rats through lymph lipid analysis. The in vitro results showed that the release of n-3 LC PUFA from lipolysis was increased by 48 % when FA were provided as PL rather than TAG. The in vivo results demonstrated that EPA and DHA from both TAG and PL were similarly absorbed and incorporated into lymph lipids. However, DHA was mainly distributed at the sn-1/3 positions of lymph TAG when provided as marine PL, whereas it was equally distributed at the three positions with marine TAG. On the whole, even if the molecular lipid species of n-3 LC PUFA did not greatly modify the in vivo digestion and absorption steps, it modulated the rearrangement of DHA on the glyceride positions of the lymph TAG, which may further impact the DHA metabolic fate and tissue accretion. Consequently, the present study has provided data which may be used to formulate lipid diets rich in DHA in the context of an insufficient consumption of n-3 PUFA in Western countries.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enn-3 PUFA
dc.subject.enTAG
dc.subject.enPhospholipids
dc.subject.enBioavailability
dc.subject.enLymph
dc.subject.en2-monoglycerides
dc.subject.enchylomicrons
dc.subject.enfatty acids
dc.subject.enlong chain
dc.subject.enphospholipids
dc.subject.enphospholipase A2
dc.title.enIn vitro lipolysis and lymphatic absorption of n-3 long-chain PUFA in the rat: influence of the molecular lipid species as carrier
dc.typeArticle de revueen_US
dc.identifier.doi10.1017/s0007114519001491en_US
dc.subject.halChimie/Matériauxen_US
bordeaux.journalBritish Journal of Nutritionen_US
bordeaux.page639-647en_US
bordeaux.volume122en_US
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-02565501
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=British%20Journal%20of%20Nutrition&rft.date=2019&rft.volume=122&rft.issue=6&rft.spage=639-647&rft.epage=639-647&rft.eissn=0007-1145&rft.issn=0007-1145&rft.au=SEHL,%20Anthony&COUEDELO,%20Leslie&CHAMEKH-COELHO,%20Ikram&VAYSSE,%20Carole&CANSELL,%20Maud&rft.genre=article


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