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dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMARIE, Anais
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDARRICAU, Morgane
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorTOUYAROT, Katia
dc.contributor.authorPARR-BROWNLIE, Louise C
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBOSCH BOUJU, Clementine
ORCID: 0000-0001-8869-768X
IDREF: 156530244
dc.date.accessioned2021-07-16T07:48:25Z
dc.date.available2021-07-16T07:48:25Z
dc.date.issued2021-06-05
dc.identifier.issn1877-718Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/109270
dc.description.abstractEnEvidence shows that altered retinoic acid signaling may contribute to the pathogenesis and pathophysiology of Parkinson's disease (PD). Retinoic acid is the bioactive derivative of the lipophilic vitamin A. Vitamin A is involved in several important homeostatic processes, such as cell differentiation, antioxidant activity, inflammation and neuronal plasticity. The role of vitamin A and its derivatives in the pathogenesis and pathophysiology of neurodegenerative diseases, and their potential as therapeutics, has drawn attention for more than 10 years. However, the literature sits in disparate fields. Vitamin A could act at the crossroad of multiple environmental and genetic factors of PD. The purpose of this review is to outline what is known about the role of vitamin A metabolism in the pathogenesis and pathophysiology of PD. We examine key biological systems and mechanisms that are under the control of vitamin A and its derivatives, which are (or could be) exploited for therapeutic potential in PD: the survival of dopaminergic neurons, oxidative stress, neuroinflammation, circadian rhythms, homeostasis of the enteric nervous system, and hormonal systems. We focus on the pivotal role of ALDH1A1, an enzyme expressed by dopaminergic neurons for the detoxification of these neurons, which is under the control of retinoic acid. By providing an integrated summary, this review will guide future studies on the potential role of vitamin A in the management of symptoms, health and wellbeing for PD patients.
dc.language.isoENen_US
dc.subject.enNeuroinflammation
dc.subject.enVitamin A
dc.subject.enRetinoic acid
dc.subject.enALDH1A1
dc.subject.enOxidative stress
dc.subject.enRAR RXR receptors
dc.title.enRole and Mechanism of Vitamin A Metabolism in the Pathophysiology of Parkinson's Disease.
dc.title.alternativeJ Parkinsons Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3233/JPD-212671en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed34120916en_US
bordeaux.journalJournal of Parkinson's diseaseen_US
bordeaux.page1-22en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAssociation France Parkinsonen_US
bordeaux.identifier.funderIDHealth Research Council of New Zealanden_US
bordeaux.identifier.funderIDBrain Research New Zealanden_US
bordeaux.import.sourcepubmed
hal.identifierhal-03288013
hal.version1
hal.date.transferred2021-07-16T07:48:28Z
hal.exporttrue
workflow.import.sourcepubmed
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