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dc.contributor.authorBORRE, Etienne
dc.contributor.authorDAHM, Georges
dc.contributor.authorGUICHARD, Gilles
IDREF: 084339268
dc.contributor.authorBELLEMIN-LAPONNAZ, Stephane
dc.date.accessioned2020-09-03T07:56:27Z
dc.date.available2020-09-03T07:56:27Z
dc.date.issued2016
dc.identifier.issn1144-0546
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10903
dc.description.abstractEnCarbonyl condensation reactions such as imine, hydrazine, and oxime-bond formation have been successfully used for accessing N-heterocyclic carbene platinum bioconjugate complexes. Among all the synthesized compounds, oxime-containing complexes were found to display a high hydrolytic stability and were found to be stable on silica gel or in wet solvents. As a proof of concept, the Pt NHC complexes were finally functionalized with three selective ligand-targeting moieties using oxime ligation. Preliminary results of the biological effects on various human cancer and non-cancer cells are also reported.
dc.language.isoen
dc.title.enPost-functionalization of platinum-NHC complexes by oxime ligation for ligand targeted therapy
dc.typeArticle de revue
dc.subject.halChimie/Matériaux
bordeaux.journalNew Journal of Chemistry
bordeaux.page3164-3171
bordeaux.volume40
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.issue4
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=New%20Journal%20of%20Chemistry&rft.date=2016&rft.volume=40&rft.issue=4&rft.spage=3164-3171&rft.epage=3164-3171&rft.eissn=1144-0546&rft.issn=1144-0546&rft.au=BORRE,%20Etienne&DAHM,%20Georges&GUICHARD,%20Gilles&BELLEMIN-LAPONNAZ,%20Stephane&rft.genre=article


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