Post-functionalization of platinum-NHC complexes by oxime ligation for ligand targeted therapy
| dc.contributor.author | BORRE, Etienne | |
| dc.contributor.author | DAHM, Georges | |
| dc.contributor.author | GUICHARD, Gilles
IDREF: 084339268 | |
| dc.contributor.author | BELLEMIN-LAPONNAZ, Stephane | |
| dc.date.accessioned | 2020-09-03T07:56:27Z | |
| dc.date.available | 2020-09-03T07:56:27Z | |
| dc.date.issued | 2016 | |
| dc.identifier.issn | 1144-0546 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/10903 | |
| dc.description.abstractEn | Carbonyl condensation reactions such as imine, hydrazine, and oxime-bond formation have been successfully used for accessing N-heterocyclic carbene platinum bioconjugate complexes. Among all the synthesized compounds, oxime-containing complexes were found to display a high hydrolytic stability and were found to be stable on silica gel or in wet solvents. As a proof of concept, the Pt NHC complexes were finally functionalized with three selective ligand-targeting moieties using oxime ligation. Preliminary results of the biological effects on various human cancer and non-cancer cells are also reported. | |
| dc.language.iso | en | |
| dc.title.en | Post-functionalization of platinum-NHC complexes by oxime ligation for ligand targeted therapy | |
| dc.type | Article de revue | |
| dc.subject.hal | Chimie/Matériaux | |
| bordeaux.journal | New Journal of Chemistry | |
| bordeaux.page | 3164-3171 | |
| bordeaux.volume | 40 | |
| bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248 | * |
| bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248) | |
| bordeaux.issue | 4 | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=New%20Journal%20of%20Chemistry&rft.date=2016&rft.volume=40&rft.issue=4&rft.spage=3164-3171&rft.epage=3164-3171&rft.eissn=1144-0546&rft.issn=1144-0546&rft.au=BORRE,%20Etienne&DAHM,%20Georges&GUICHARD,%20Gilles&BELLEMIN-LAPONNAZ,%20Stephane&rft.genre=article |
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