BORRE, Etienne; DAHM, Georges; GUICHARD, Gilles; BELLEMIN-LAPONNAZ, Stephane

Metadatos

Mostrar el registro completo del ítem

Licencia de uso del documento

Idioma

Article de revue

Este ítem está publicado en

New Journal of Chemistry. 2016, vol. 40, n° 4, p. 3164-3171

Resumen en inglés

Carbonyl condensation reactions such as imine, hydrazine, and oxime-bond formation have been successfully used for accessing N-heterocyclic carbene platinum bioconjugate complexes. Among all the synthesized compounds, oxime-containing complexes were found to display a high hydrolytic stability and were found to be stable on silica gel or in wet solvents. As a proof of concept, the Pt NHC complexes were finally functionalized with three selective ligand-targeting moieties using oxime ligation. Preliminary results of the biological effects on various human cancer and non-cancer cells are also reported.< Leer menos

URI

https://oskar-bordeaux.fr/handle/20.500.12278/10903

Centros de investigación

CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248