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Study of potential anti-inflammatory effects of red wine extract and resveratrol through a modulation of interleukin-1-Beta in macrophages

dc.rights.licenseopenen_US
dc.contributor.authorCHALONS, Pauline
dc.contributor.authorAMOR, Souheila
dc.contributor.authorCOURTAUT, Flavie
dc.contributor.authorCANTOS-VILLAR, Emma
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorRICHARD, Tristan
dc.contributor.authorAUGER, Cyril
dc.contributor.authorCHABERT, Philippe
dc.contributor.authorSCHNI-KERTH, Valérie
dc.contributor.authorAIRES, Virginie
dc.contributor.authorDELMAS, Dominique
dc.date.accessioned2020-08-28T13:47:18Z
dc.date.available2020-08-28T13:47:18Z
dc.date.issued2018
dc.identifier.issn2072-6643en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10706
dc.description.abstractEnInflammation has been described as an initiator event of major diseases with significant impacts in terms of public health including in cardiovascular disease, autoimmune disorders, eye diseases, age-related diseases, and the occurrence of cancers. A preventive action to reduce the key processes leading to inflammation could be an advantageous approach to reducing these associated pathologies. Many studies have reported the value of polyphenols such as resveratrol in counteracting pro-inflammatory cytokines. We have previously shown the potential of red wine extract (RWE) and the value of its qualitative and quantitative polyphenolic composition to prevent the carcinogenesis process. In this study, we addressed a new effect of RWE in inflammation through a modulation of IL-1β secretion and the NLRP3 inflammasome pathway. NLRP3 inflammasome requires two signals, priming to increase the synthesis of NLRP3 and pro-IL-1β proteins and activation, which activates NLRP3. Inflammasome formation is triggered by a range of substances such as lipopolysaccharide (LPS). Using two different macrophages, one of which does not express the adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which is essential to form active inflammasome complexes that produce IL-1β, we show that RWE decreases IL-1 β secretion and gene expression whatever line is used. Moreover, this strong reduction of pro-inflammatory IL-1β is associated with a decrease of NLRP3 and, in J774A, ASC protein expression, which depends on the choice of activator ATP or nigericin.
dc.language.isoENen_US
dc.subject.enInflammation
dc.subject.enInterleukins
dc.subject.enPolyphenols
dc.subject.enRed Wine Extract
dc.subject.enResveratrol
dc.title.enStudy of potential anti-inflammatory effects of red wine extract and resveratrol through a modulation of interleukin-1-Beta in macrophages
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/nu10121856en_US
dc.subject.halSciences du Vivant [q-bio]/Biologie végétaleen_US
dc.identifier.pubmed30513737en_US
bordeaux.journalNutrientsen_US
bordeaux.page1-17en_US
bordeaux.volume10en_US
bordeaux.hal.laboratoriesOenologie - EA 4577en_US
bordeaux.issue12en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nutrients&rft.date=2018&rft.volume=10&rft.issue=12&rft.spage=1-17&rft.epage=1-17&rft.eissn=2072-6643&rft.issn=2072-6643&rft.au=CHALONS,%20Pauline&AMOR,%20Souheila&COURTAUT,%20Flavie&CANTOS-VILLAR,%20Emma&RICHARD,%20Tristan&rft.genre=article


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