FAUQUIGNON, Martin; COURTECUISSE, Elise; JOSSELIN, Romane; MUTSCHLER, Angela; BRÛLET, Annie; SCHMUTZ, Marc; LE MEINS, Jean-Francois

doi:10.1016/j.jcis.2021.06.172

Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

COURTECUISSE, Elise
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

JOSSELIN, Romane
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

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Article de revue

Ce document a été publié dans

Journal of Colloid and Interface Science. 2021-07-06

Résumé en anglais

Membrane structuration of Large Hybrid Unilamellar Polymer/Lipid Vesicle (LHUV) is an important parameter on the optimization of their properties and thus their valuation in various fields. However, this kind of information is hardly accessible. In this work, we will focus on the development of LHUV obtained from the self-assembly of diblock poly(dimethylsiloxane)-b-poly(ethylene oxide) (PDMS-b-PEO) of different molar masses combined with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) at 15% and 25% w/w content. The hybrid character of the resulting vesicles as well as their membrane structure are characterized by the mean of different techniques such as small-angle neutron scattering (SANS) and cryo-transmission electron microscopy (cryo-TEM). We show that hybrid vesicles with homogeneous membrane structure are obtained whatever the molar mass of the block copolymer (from 2500 to 4000g/mol), with of a small number of tubular structures observed with the higher molar mass. We also demonstrate that the permeability of the LHUV, evaluated through controlled release experiments of fluorescein loaded in LHUV, is essentially controlled by the lipid/polymer composition.< Réduire

Mots clés en anglais

Hybrid Polymer/Lipid Vesicle

Membrane Permeability

Polymersomes

Liposomes

Small Angle Neutron Scattering (SANS)

Cryo Transmission Electron Microscopy (Cryo-TEM)

Nanoreactor

URI

https://oskar-bordeaux.fr/handle/20.500.12278/106531

DOI

http://dx.doi.org/10.1016/j.jcis.2021.06.172

Unités de recherche

Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629

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Large Hybrid Polymer/Lipid Unilamellar Vesicle (LHUV) at the nanoscale: An insight into the lipid distribution in the membrane and permeability control

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Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche