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Chondroprotective properties of human-enriched serum following polyphenol extract absorption: results from an exploratory clinical trial

dc.rights.licenseopenen_US
dc.relation.isnodoublefd936fb8-8093-4c8f-ac1a-efcb9b585d7b*
dc.relation.isnodoubleee8c8fc6-9149-40f8-a2ca-181952001594*
dc.relation.isnodouble722978d2-8240-44b7-ba50-158ae65410cf*
dc.contributor.authorWAUQUIER, Fabien
dc.contributor.authorMEVEL, Elsa
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorKRISA, Stephanie
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorRICHARD, Tristan
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorVALLS FONAYET, Josep
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorHORNEDO ORTEGA, Ruth
dc.contributor.authorGRANEL, Henri
dc.contributor.authorWITTRANT, Line
dc.contributor.authorURBAN, Nelly
dc.contributor.authorBERGER, Juliette
dc.contributor.authorDESCAMPS, Stephane
dc.contributor.authorGUICHEUX, Jerome
dc.contributor.authorVINATIER, Claire S.
dc.contributor.authorBECK, Laurent
dc.contributor.authorMEUNIER, Nathalie
dc.contributor.authorBLOT, Adeline
dc.contributor.authorWITTRANT, Yohann
dc.date.accessioned2020-07-07T10:17:26Z
dc.date.available2020-07-07T10:17:26Z
dc.date.issued2019
dc.identifier.issn2072-6643en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10174
dc.description.abstractEnPolyphenols are widely acknowledged for their health benefits, especially for the prevention of inflammatory and age-related diseases. We previously demonstrated that hydroxytyrosol (HT) and procyanidins (PCy), alone or in combination, drive preventive anti-osteoathritic effects in vivo. However, the lack of sufficient clinical evidences on the relationship between dietary phytochemicals and osteoarthritis remains. In this light, we investigated in humans the potential osteoarticular benefit of a grapeseed and olive extract (OPCO) characterized for its hydroxytyrosol (HT) and procyanidins (PCy) content. We first validated, in vitro, the anti-inflammatory and chondroprotective properties of the extract on primary cultured human articular chondrocytes stimulated by interleukin-1 beta (IL-1 beta). The sparing effect involved a molecular mechanism dependent on the nuclear transcription factor-kappa B (NF-kappa B) pathway. To confirm the clinical relevance of such a nutritional strategy, we designed an innovative clinical approach taking into account the metabolites that are formed during the digestion process and that appear in circulation after the ingestion of the OPCO extract. Blood samples from volunteers were collected following ingestion, absorption, and metabolization of the extract and then were processed and applied on human primary chondrocyte cultures. This original ex vivo methodology confirmed at a clinical level the chondroprotective properties previously observed in vitro and in vivo.
dc.language.isoENen_US
dc.subject.enMicronutrients
dc.subject.enOsteoarthritis (Oa)
dc.subject.enClinical Trials
dc.subject.enHydroxytyrosol
dc.subject.enProcyanidins
dc.subject.enCell Biology
dc.title.enChondroprotective properties of human-enriched serum following polyphenol extract absorption: results from an exploratory clinical trial
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/nu11123071en_US
dc.subject.halSciences du Vivant [q-bio]/Biologie végétaleen_US
dc.identifier.pubmed31888255en_US
bordeaux.journalNutrientsen_US
bordeaux.page1-16en_US
bordeaux.volume11en_US
bordeaux.hal.laboratoriesOenologie - EA 4577en_US
bordeaux.issue12en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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