PONS, Romain; BOULANGER, Mathilde; TUAL, Severine; BUSSON, Amandine; RENIER, Marine; PERRIER, Stéphanie; LEVEQUE-MORLAIS, Noemie; MARCOTULLIO, Elisabeth; BALDI, Isabelle; LEBAILLY, Pierre

doi:10.1097/jom.0000000000002163

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Journal of Occupational and Environmental Medicine. 2021-05-01, vol. 63, n° 5, p. 432-440

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OBJECTIVES: In few retrospective studies, prolonged time-to-pregnancy (TTP) was observed for women exposed to pesticides especially in flower production. The present study investigated time-to-pregnancy in the AGRICAN cohort. METHODS: Analyses were performed on 616 women reporting a pregnancy (2005 to 2017), and data on agricultural activities performed before the last pregnancy was retrospectively collected. Fecundability odds ratios (fOR) were estimated using a discrete time analogue of Cox proportional hazard model adjusted on maternal and paternal age, body mass index (BMI), and alcohol consumption. RESULTS: A decrease in fecundability was non-significantly associated with farm work (adjusted fOR = 0.86; 95% confidence interval [CI]: 0.71 to 1.05). Decreases were also observed for nightwork (afOR = 0.75; 95% CI: 0.49 to 1.15) and exposure to vibrations (afOR = 0.68; 95% CI: 0.43 to 1.09). CONCLUSION: Women working on a farm before conception appeared to experience a longer TTP. Negative associations were suggested for some agricultural activities and working conditions.< Réduire

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Agriculture Exposure and Time to Pregnancy Among Women Enrolled in the French Prospective Cohort AGRICAN

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